Seroatlas · Human Serome Atlas

RAI2

Retinoic acid-induced protein 2

Also known as: RAI2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y5P3
Gene: RAI2
Ensembl: ENSG00000131831
Chromosome: X
Canonical length: 530 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

Retinoic acid plays a critical role in development, cellular growth, and differentiation. The specific function of this retinoic acid-induced gene has not yet been determined but it may play a role in development. The chromosomal location of this gene designates it to be a candidate for diseases such as Nance-Horan syndrome, sensorineural deafness, non-specific X-linked cognitive disability, oral-facial-digital syndrome, and Fried syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Canonical amino-acid sequenceUniProt

530 residues, UniProt reviewed canonical sequence.

>Q9Y5P3|RAI2
     1  MDDLQSQNLS MDMTDSPPAL ANNRLENGMA QLITTEAWNI NSTDLVKKAL VTVPAPSILN
    61  PPAESQSGMA LKVAATVLQP LCLGESPVVM PIHMQVEGSS APELNPNGNA TYVMTTQGPV
   121  QLPVVLEQHV FQHLNSPLVL PQEAPCSSST IHNNLFQGAE DPEAQPQLLD LRIPSQPQEP
   181  TLPFEAVLQN LFPSQGTLGP PPCQPPPGYA PVPPQPFSSP LSPLVPPATL LVPYPVIVPL
   241  PVPVPIPIPI PMPQSSESKF SSSFPKPPSS FGLHPFKGTQ TPLEKDELKP FDILQPKEYF
   301  QLSRHTVIKM GSENEALDLS MKSVPWLKAG EVSPPIFQED AALDLSVAAH RKSEPPPETL
   361  YDSGASVDSS GHTVMEKLPS GMEISFAPAT SHEAPAMMDS HISSSDAATE MLSQPNHPSG
   421  EVKAENNIEM VGESQAAKVI VSVEDAVPTI FCGKIKGLSG VSTKNFSFKR EDSVLQGYDI
   481  NSQGEESMGN AEPLRKPIKN RSIKLKKVNS QEIHMLPIKK QRLATFFPRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAI2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 67 nTPM

Expression across tissuesHPA

Tissue

endometrium: 67 nTPM
fallopian tube: 61 nTPM
ovary: 48 nTPM
cervix: 48 nTPM
breast: 46 nTPM
adipose tissue: 46 nTPM

Single-cell type

endometrial luminal cells: 121 nCPM
endometrial glandular cells: 79 nCPM
peritubular myoid cells: 78 nCPM
salivary myoepithelial cells: 78 nCPM
neuroendocrine cells: 69 nCPM
salivary basal cells: 60 nCPM

Immune cell

naive CD8 T-cell: 1.8 nTPM
naive CD4 T-cell: 0.5 nTPM
memory CD4 T-cell: 0.1 nTPM
NK-cell: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM

Brain region

cerebral cortex: 14 nTPM
thalamus: 14 nTPM
pons: 12 nTPM
medulla oblongata: 12 nTPM
amygdala: 11 nTPM
hypothalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.66
gnomAD pLI: 0.61
gnomAD missense Z: -0.06
DepMap mean gene effect: 0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

InteractionsUniProt · HPA

Protein binding partners of RAI2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAI2 as an antibody target. Whether an autoantibody or antibody against RAI2 could matter depends on whether native RAI2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAI2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAI2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...