Seroatlas · Human Serome Atlas

FAM107A

Actin-associated protein FAM107A

Also known as: DRR1, F107A_HUMAN, TU3A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95990
Gene: FAM107A
Ensembl: ENSG00000168309
Chromosome: 3
Canonical length: 144 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Predicted to enable actin binding activity. Involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; negative regulation of focal adhesion assembly; and regulation of cytoskeleton organization. Located in several cellular components, including focal adhesion; ruffle membrane; and stress fiber. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

144 residues, UniProt reviewed canonical sequence.

>O95990|FAM107A
     1  MYSEIQRERA DIGGLMARPE YREWNPELIK PKKLLNPVKA SRSHQELHRE LLMNHRRGLG
    61  VDSKPELQRV LEHRRRNQLI KKKKEELEAK RLQCPFEQEL LRRQQRLNQL EKPPEKEEDH
   121  APEFIKVREN LRRIATLTSE EREL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM107A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 1,181 nTPM

Expression across tissuesHPA

Tissue

amygdala: 1,181 nTPM
cerebral cortex: 1,173 nTPM
hippocampal formation: 923 nTPM
basal ganglia: 841 nTPM
spinal cord: 826 nTPM
midbrain: 814 nTPM

Single-cell type

salivary acinar cells: 263 nCPM
pituitary stem cells: 239 nCPM
fallopian secretory cells: 220 nCPM
lacrimal acinar cells: 218 nCPM
bergmann glia: 209 nCPM
cone photoreceptor cells: 205 nCPM

Immune cell

basophil: 0.1 nTPM
non-classical monocyte: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 1,112 nTPM
amygdala: 1,111 nTPM
basal ganglia: 1,048 nTPM
white matter: 972 nTPM
hypothalamus: 937 nTPM
hippocampal formation: 935 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0
gnomAD missense Z: 0.1
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

actin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM107A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM107A as an antibody target. Whether an autoantibody or antibody against FAM107A could matter depends on whether native FAM107A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM107A is annotated at the cell surface, where native FAM107A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FAM107A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...