Seroatlas · Human Serome Atlas

SCNN1D

Epithelial sodium channel subunit delta

Also known as: dNaCh, ENaCdelta, SCNND_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P51172
Gene
SCNN1D
Ensembl
ENSG00000162572
Chromosome
1
Canonical length
802 aa
Protein class
FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane,Actin filaments

OverviewNCBI Gene

Contributes to sodium channel activity. Involved in cellular response to acidic pH; intracellular sodium ion homeostasis; and sodium ion import across plasma membrane. Located in actin cytoskeleton and membrane. Part of sodium channel complex. Is active in apical plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

802 residues, UniProt reviewed canonical sequence.

>P51172|SCNN1D
     1  MRAVLSQKTT PLPRYLWPGH LSGPRRLTWS WCSDHRTPTC RELGSPHPTP CTGPARGWPR
    61  RGGGPCGFTS AGHVLCGYPL CLLSGPIQGC GTGLGDSSMA FLSRTSPVAA ASFQSRQEAR
   121  GSILLQSCQL PPQWLSTEAW TGEWKQPHGG ALTSRSPGPV APQRPCHLKG WQHRPTQHNA
   181  ACKQGQAAAQ TPPRPGPPSA PPPPPKEGHQ EGLVELPASF RELLTFFCTN ATIHGAIRLV
   241  CSRGNRLKTT SWGLLSLGAL VALCWQLGLL FERHWHRPVL MAVSVHSERK LLPLVTLCDG
   301  NPRRPSPVLR HLELLDEFAR ENIDSLYNVN LSKGRAALSA TVPRHEPPFH LDREIRLQRL
   361  SHSGSRVRVG FRLCNSTGGD CFYRGYTSGV AAVQDWYHFH YVDILALLPA AWEDSHGSQD
   421  GHFVLSCSYD GLDCQARQFR TFHHPTYGSC YTVDGVWTAQ RPGITHGVGL VLRVEQQPHL
   481  PLLSTLAGIR VMVHGRNHTP FLGHHSFSVR PGTEATISIR EDEVHRLGSP YGHCTAGGEG
   541  VEVELLHNTS YTRQACLVSC FQQLMVETCS CGYYLHPLPA GAEYCSSARH PAWGHCFYRL
   601  YQDLETHRLP CTSRCPRPCR ESAFKLSTGT SRWPSAKSAG WTLATLGEQG LPHQSHRQRS
   661  SLAKINIVYQ ELNYRSVEEA PVYSVPQLLS AMGSLCSLWF GASVLSLLEL LELLLDASAL
   721  TLVLGGRRLR RAWFSWPRAS PASGASSIKP EASQMPPPAG GTSDDPEPSG PHLPRVMLPG
   781  VLAGVSAEES WAGPQPLETL DT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCNN1D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 36 nTPM
  • testis: 35 nTPM
  • cerebral cortex: 20 nTPM
  • pituitary gland: 18 nTPM
  • basal ganglia: 15 nTPM
  • ovary: 14 nTPM

Single-cell type

  • early spermatids: 17 nCPM
  • proximal tubule cells: 14 nCPM
  • astrocytes: 13 nCPM
  • esophageal apical cells: 13 nCPM
  • esophageal suprabasal cells: 13 nCPM
  • oligodendrocyte progenitor cells: 12 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 28 nTPM
  • cerebellum: 23 nTPM
  • white matter: 22 nTPM
  • pons: 21 nTPM
  • medulla oblongata: 20 nTPM
  • amygdala: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.59
gnomAD pLI
0
gnomAD missense Z
-0.78
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SCNN1D in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCNN1D as an antibody target. Whether an autoantibody or antibody against SCNN1D could matter depends on whether native SCNN1D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCNN1D is annotated at the cell surface, where native SCNN1D is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SCNN1D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SCNN1D. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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