Seroatlas · Human Serome Atlas

CCS

Copper chaperone for superoxide dismutase

Also known as: CCS_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14618
Gene: CCS
Ensembl: ENSG00000173992
Chromosome: 11
Canonical length: 274 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Copper chaperone for superoxide dismutase specifically delivers Cu to copper/zinc superoxide dismutase and may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

274 residues, UniProt reviewed canonical sequence.

>O14618|CCS
     1  MASDSGNQGT LCTLEFAVQM TCQSCVDAVR KSLQGVAGVQ DVEVHLEDQM VLVHTTLPSQ
    61  EVQALLEGTG RQAVLKGMGS GQLQNLGAAV AILGGPGTVQ GVVRFLQLTP ERCLIEGTID
   121  GLEPGLHGLH VHQYGDLTNN CNSCGNHFNP DGASHGGPQD SDRHRGDLGN VRADADGRAI
   181  FRMEDEQLKV WDVIGRSLII DEGEDDLGRG GHPLSKITGN SGERLACGII ARSAGLFQNP
   241  KQICSCDGLT IWEERGRPIA GKGRKESAQP PAHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 90 nTPM

Expression across tissuesHPA

Tissue

liver: 90 nTPM
adrenal gland: 45 nTPM
ovary: 44 nTPM
colon: 43 nTPM
choroid plexus: 40 nTPM
prostate: 39 nTPM

Single-cell type

platelets: 288 nCPM
hepatocytes: 194 nCPM
bergmann glia: 170 nCPM
rod photoreceptor cells: 112 nCPM
hofbauer cells: 100 nCPM
decidual stromal cells: 98 nCPM

Immune cell

plasmacytoid DC: 84 nTPM
eosinophil: 60 nTPM
memory B-cell: 33 nTPM
myeloid DC: 31 nTPM
classical monocyte: 27 nTPM
naive B-cell: 25 nTPM

Brain region

white matter: 38 nTPM
cerebellum: 35 nTPM
cerebral cortex: 35 nTPM
medulla oblongata: 34 nTPM
hypothalamus: 32 nTPM
midbrain: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0
gnomAD missense Z: 0.4
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCS in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCS as an antibody target. Whether an autoantibody or antibody against CCS could matter depends on whether native CCS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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