Seroatlas · Human Serome Atlas

RELB

Transcription factor RelB

Also known as: REL-B, RELB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q01201
Gene
RELB
Ensembl
ENSG00000104856
Chromosome
19
Canonical length
579 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and protein kinase binding activity. Involved in lymphocyte differentiation and negative regulation of interferon-beta production. Located in several cellular components, including centrosome; chromatin; and nucleoplasm. Part of nucleus and transcription repressor complex. Implicated in breast cancer and immunodeficiency 53. Biomarker of breast cancer and transitional cell carcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

579 residues, UniProt reviewed canonical sequence.

>Q01201|RELB
     1  MLRSGPASGP SVPTGRAMPS RRVARPPAAP ELGALGSPDL SSLSLAVSRS TDELEIIDEY
    61  IKENGFGLDG GQPGPGEGLP RLVSRGAASL STVTLGPVAP PATPPPWGCP LGRLVSPAPG
   121  PGPQPHLVIT EQPKQRGMRF RYECEGRSAG SILGESSTEA SKTLPAIELR DCGGLREVEV
   181  TACLVWKDWP HRVHPHSLVG KDCTDGICRV RLRPHVSPRH SFNNLGIQCV RKKEIEAAIE
   241  RKIQLGIDPY NAGSLKNHQE VDMNVVRICF QASYRDQQGQ MRRMDPVLSE PVYDKKSTNT
   301  SELRICRINK ESGPCTGGEE LYLLCDKVQK EDISVVFSRA SWEGRADFSQ ADVHRQIAIV
   361  FKTPPYEDLE IVEPVTVNVF LQRLTDGVCS EPLPFTYLPR DHDSYGVDKK RKRGMPDVLG
   421  ELNSSDPHGI ESKRRKKKPA ILDHFLPNHG SGPFLPPSAL LPDPDFFSGT VSLPGLEPPG
   481  GPDLLDDGFA YDPTAPTLFT MLDLLPPAPP HASAVVCSGG AGAVVGETPG PEPLTLDSYQ
   541  APGPGDGGTA SLVGSNMFPN HYREAAFGGG LLSPGPEAT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RELB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 34 nTPM
  • spleen: 25 nTPM
  • lung: 21 nTPM
  • kidney: 17 nTPM
  • lymph node: 17 nTPM
  • appendix: 16 nTPM

Single-cell type

  • neutrophils: 625 nCPM
  • enterocytes: 323 nCPM
  • mast cells: 295 nCPM
  • colonocytes: 206 nCPM
  • monocytes: 197 nCPM
  • pancreatic duct cells: 195 nCPM

Immune cell

  • neutrophil: 16 nTPM
  • memory B-cell: 9.2 nTPM
  • naive B-cell: 7.7 nTPM
  • classical monocyte: 5.2 nTPM
  • plasmacytoid DC: 4.1 nTPM
  • myeloid DC: 3.9 nTPM

Brain region

  • medulla oblongata: 8.4 nTPM
  • thalamus: 8.2 nTPM
  • cerebral cortex: 6.7 nTPM
  • white matter: 6.5 nTPM
  • pons: 6.2 nTPM
  • spinal cord: 5.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RELB.

Disease | AllUniProt

Conditions RELB is implicated in, by any mechanism.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 539 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Immunodeficiency 53

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.26
gnomAD pLI
0.99
gnomAD missense Z
2.28
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RELB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RELB as an antibody target. Whether an autoantibody or antibody against RELB could matter depends on whether native RELB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RELB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RELB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RELB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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