Seroatlas · Human Serome Atlas

COMMD7

COMM domain-containing protein 7

Also known as: C20orf92, COMD7_HUMAN, dJ1085F17.3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86VX2
Gene: COMMD7
Ensembl: ENSG00000149600
Chromosome: 20
Canonical length: 200 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Enables NF-kappaB binding activity. Involved in negative regulation of DNA-templated transcription; negative regulation of NF-kappaB transcription factor activity; and tumor necrosis factor-mediated signaling pathway. Predicted to be located in cytoplasmic vesicle and membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

200 residues, UniProt reviewed canonical sequence.

>Q86VX2|COMMD7
     1  MGRLHCTEDP VPEAVGGDMQ QLNQLGAQQF SALTEVLFHF LTEPKEVERF LAQLSEFATT
    61  NQISLGSLRS IVKSLLLVPN GALKKSLTAK QVQADFITLG LSEEKATYFS EKWKQNAPTL
   121  ARWAIGQTLM INQLIDMEWK FGVTSGSSEL EKVGSIFLQL KLVVKKGNQT ENVYIELTLP
   181  QFYSFLHEME RVRTSMECFC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COMMD7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 62 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 62 nTPM
heart muscle: 61 nTPM
kidney: 59 nTPM
cerebral cortex: 56 nTPM
amygdala: 54 nTPM
tongue: 51 nTPM

Single-cell type

tuft cells: 12 nCPM
oocytes: 4.6 nCPM
retinal pigment epithelial cells: 4.3 nCPM
schwann cells: 2.6 nCPM
respiratory ionocytes: 2.5 nCPM
megakaryocyte-erythroid progenitors: 1.5 nCPM

Immune cell

total PBMC: 166 nTPM
non-classical monocyte: 166 nTPM
eosinophil: 163 nTPM
intermediate monocyte: 144 nTPM
myeloid DC: 123 nTPM
basophil: 117 nTPM

Brain region

midbrain: 36 nTPM
cerebral cortex: 35 nTPM
thalamus: 35 nTPM
basal ganglia: 33 nTPM
amygdala: 31 nTPM
hypothalamus: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0
gnomAD missense Z: 0.59
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

NF-kappaB binding

Cellular components

cytoplasmic vesicle

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COMMD7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COMMD7 as an antibody target. Whether an autoantibody or antibody against COMMD7 could matter depends on whether native COMMD7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COMMD7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COMMD7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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