Seroatlas · Human Serome Atlas

CLU

Clusterin

Also known as: APOJ, CLI, CLU1, CLU2, CLUS_HUMAN, KUB1, SGP-2, SP-40, TRPM-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P10909
Gene
CLU
Ensembl
ENSG00000120885
Chromosome
8
Canonical length
449 aa
Protein class
Cancer-related genes, Candidate cardiovascular disease genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Cytosol
Secretome location
Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011]

Canonical amino-acid sequenceUniProt

449 residues, UniProt reviewed canonical sequence.

>P10909|CLU
     1  MMKTLLLFVG LLLTWESGQV LGDQTVSDNE LQEMSNQGSK YVNKEIQNAV NGVKQIKTLI
    61  EKTNEERKTL LSNLEEAKKK KEDALNETRE SETKLKELPG VCNETMMALW EECKPCLKQT
   121  CMKFYARVCR SGSGLVGRQL EEFLNQSSPF YFWMNGDRID SLLENDRQQT HMLDVMQDHF
   181  SRASSIIDEL FQDRFFTREP QDTYHYLPFS LPHRRPHFFF PKSRIVRSLM PFSPYEPLNF
   241  HAMFQPFLEM IHEAQQAMDI HFHSPAFQHP PTEFIREGDD DRTVCREIRH NSTGCLRMKD
   301  QCDKCREILS VDCSTNNPSQ AKLRRELDES LQVAERLTRK YNELLKSYQW KMLNTSSLLE
   361  QLNEQFNWVS RLANLTQGED QYYLRVTTVA SHTSDSDVPS GVTEVVVKLF DSDPITVTVP
   421  VEVSRKNPKF METVAEKALQ EYRKKHREE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLU can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
9,103 nTPM

Expression across tissuesHPA

Tissue

  • liver: 9,103 nTPM
  • epididymis: 8,617 nTPM
  • basal ganglia: 7,364 nTPM
  • cerebral cortex: 6,578 nTPM
  • choroid plexus: 6,281 nTPM
  • amygdala: 6,088 nTPM

Single-cell type

  • ocular epithelial cells: 11,976 nCPM
  • müller glia: 7,063 nCPM
  • epididymal efferent duct absorptive cells: 6,925 nCPM
  • endometrial secretory cells: 6,415 nCPM
  • epididymal principal cells: 6,408 nCPM
  • fallopian secretory cells: 6,164 nCPM

Immune cell

  • total PBMC: 1,075 nTPM
  • basophil: 773 nTPM
  • neutrophil: 80 nTPM
  • memory CD4 T-cell: 23 nTPM
  • memory CD8 T-cell: 21 nTPM
  • gdT-cell: 20 nTPM

Brain region

  • medulla oblongata: 12,486 nTPM
  • white matter: 11,065 nTPM
  • spinal cord: 9,469 nTPM
  • midbrain: 8,703 nTPM
  • hypothalamus: 8,081 nTPM
  • thalamus: 6,382 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CLU.

Disease | ImmuneIEDB

Conditions an epitope on CLU was assayed in.

ReferencesPubMed · IEDB

Publications for CLU from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

2 publications

Reference: B cellIEDB

2 publications

Reference: T cellIEDB

1 publication

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.83
gnomAD pLI
0
gnomAD missense Z
0.8
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CLU in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLU as an antibody target. Whether an autoantibody or antibody against CLU could matter depends on whether native CLU is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLU is annotated as secreted, so native CLU circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CLU as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CLU. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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