Seroatlas · Human Serome Atlas

SGK1

Serine/threonine-protein kinase Sgk1

Also known as: SGK, SGK1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O00141
Gene: SGK1
Ensembl: ENSG00000118515
Chromosome: 6
Canonical length: 431 aa
Protein class: Cancer-related genes, Enzymes, Predicted intracellular proteins
Subcellular location: Nuclear speckles
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

431 residues, UniProt reviewed canonical sequence.

>O00141|SGK1
     1  MTVKTEAAKG TLTYSRMRGM VAILIAFMKQ RRMGLNDFIQ KIANNSYACK HPEVQSILKI
    61  SQPQEPELMN ANPSPPPSPS QQINLGPSSN PHAKPSDFHF LKVIGKGSFG KVLLARHKAE
   121  EVFYAVKVLQ KKAILKKKEE KHIMSERNVL LKNVKHPFLV GLHFSFQTAD KLYFVLDYIN
   181  GGELFYHLQR ERCFLEPRAR FYAAEIASAL GYLHSLNIVY RDLKPENILL DSQGHIVLTD
   241  FGLCKENIEH NSTTSTFCGT PEYLAPEVLH KQPYDRTVDW WCLGAVLYEM LYGLPPFYSR
   301  NTAEMYDNIL NKPLQLKPNI TNSARHLLEG LLQKDRTKRL GAKDDFMEIK SHVFFSLINW
   361  DDLINKKITP PFNPNVSGPN DLRHFDPEFT EEPVPNSIGK SPDSVLVTAS VKEAAEAFLG
   421  FSYAPPTDSF L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SGK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 946 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 946 nTPM
small intestine: 266 nTPM
pancreas: 167 nTPM
gallbladder: 159 nTPM
choroid plexus: 146 nTPM
adipose tissue: 135 nTPM

Single-cell type

choroid plexus epithelial cells: 1,174 nCPM
enterocytes: 920 nCPM
oligodendrocytes: 763 nCPM
syncytiotrophoblasts: 733 nCPM
cdc: 699 nCPM
endometrial glandular cells: 683 nCPM

Immune cell

eosinophil: 170 nTPM
neutrophil: 92 nTPM
classical monocyte: 44 nTPM
intermediate monocyte: 24 nTPM
non-classical monocyte: 15 nTPM
myeloid DC: 14 nTPM

Brain region

choroid plexus: 194 nTPM
white matter: 181 nTPM
medulla oblongata: 123 nTPM
thalamus: 105 nTPM
basal ganglia: 104 nTPM
cerebral cortex: 90 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SGK1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 82 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Multiple myeloma

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.58
gnomAD pLI: 0
gnomAD missense Z: 1.25
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SGK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SGK1 as an antibody target. Whether an autoantibody or antibody against SGK1 could matter depends on whether native SGK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SGK1 is annotated at the cell surface, where native SGK1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SGK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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