Seroatlas · Human Serome Atlas

ANAPC16

Anaphase-promoting complex subunit 16

Also known as: APC16, APC16_HUMAN, bA570G20.3, C10orf104, CENP-27, FLJ33728

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96DE5
Gene: ANAPC16
Ensembl: ENSG00000166295
Chromosome: 10
Canonical length: 110 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Involved in anaphase-promoting complex-dependent catabolic process and protein polyubiquitination. Located in cytosol and kinetochore. Part of anaphase-promoting complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

110 residues, UniProt reviewed canonical sequence.

>Q96DE5|ANAPC16
     1  MAASSSSSSA GGVSGSSVTG SGFSVSDLAP PRKALFTYPK GAGEMLEDGS ERFLCESVFS
    61  YQVASTLKQV KHDQQVARME KLAGLVEELE ADEWRFKPIE QLLGFTPSSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANAPC16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 57 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 57 nTPM
heart muscle: 42 nTPM
tongue: 39 nTPM
pancreas: 32 nTPM
blood vessel: 31 nTPM
parathyroid gland: 31 nTPM

Single-cell type

parietal cells: 688 nCPM
gastric chief cells: 651 nCPM
esophageal apical cells: 567 nCPM
hepatocytes: 559 nCPM
esophageal suprabasal cells: 446 nCPM
myonuclei: 428 nCPM

Immune cell

naive B-cell: 66 nTPM
memory B-cell: 60 nTPM
naive CD4 T-cell: 48 nTPM
plasmacytoid DC: 45 nTPM
basophil: 40 nTPM
eosinophil: 38 nTPM

Brain region

cerebellum: 22 nTPM
choroid plexus: 20 nTPM
white matter: 17 nTPM
medulla oblongata: 17 nTPM
basal ganglia: 16 nTPM
pons: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.42
gnomAD pLI: 0.02
gnomAD missense Z: 0.81
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Anaphase-promoting complex subunit 16
Anaphase-promoting complex, subunit 16

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANAPC16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANAPC16 as an antibody target. Whether an autoantibody or antibody against ANAPC16 could matter depends on whether native ANAPC16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANAPC16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANAPC16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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