Seroatlas · Human Serome Atlas

CDC16

Cell division cycle protein 16 homolog

Also known as: ANAPC6, APC6, CDC16_HUMAN, CUT9

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13042
Gene: CDC16
Ensembl: ENSG00000130177
Chromosome: 13
Canonical length: 620 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degredation by the 26S proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain; a protein domain that is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants, encoding distinct proteins, have been identified. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

620 residues, UniProt reviewed canonical sequence.

>Q13042|CDC16
     1  MNLERLRKRV RQYLDQQQYQ SALFWADKVA SLSREEPQDI YWLAQCLYLT AQYHRAAHAL
    61  RSRKLDKLYE ACRYLAARCH YAAKEHQQAL DVLDMEEPIN KRLFEKYLKD ESGFKDPSSD
   121  WEMSQSSIKS SICLLRGKIY DALDNRTLAT YSYKEALKLD VYCFEAFDLL TSHHMLTAQE
   181  EKELLESLPL SKLCNEEQEL LRFLFENKLK KYNKPSETVI PESVDGLQEN LDVVVSLAER
   241  HYYNCDFKMC YKLTSVVMEK DPFHASCLPV HIGTLVELNK ANELFYLSHK LVDLYPSNPV
   301  SWFAVGCYYL MVGHKNEHAR RYLSKATTLE KTYGPAWIAY GHSFAVESEH DQAMAAYFTA
   361  AQLMKGCHLP MLYIGLEYGL TNNSKLAERF FSQALSIAPE DPFVMHEVGV VAFQNGEWKT
   421  AEKWFLDALE KIKAIGNEVT VDKWEPLLNN LGHVCRKLKK YAEALDYHRQ ALVLIPQNAS
   481  TYSAIGYIHS LMGNFENAVD YFHTALGLRR DDTFSVTMLG HCIEMYIGDS EAYIGADIKD
   541  KLKCYDFDVH TMKTLKNIIS PPWDFREFEV EKQTAEETGL TPLETSRKTP DSRPSLEETF
   601  EIEMNESDMM LETSMSDHST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDC16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 58 nTPM
epididymis: 47 nTPM
liver: 47 nTPM
pancreas: 44 nTPM
fallopian tube: 43 nTPM
spleen: 41 nTPM

Single-cell type

respiratory ciliated cells: 115 nCPM
fallopian tube ciliated cells: 113 nCPM
thyrotrophs: 110 nCPM
platelets: 107 nCPM
leydig cells: 92 nCPM
adrenal cortex cells: 91 nCPM

Immune cell

NK-cell: 11 nTPM
memory B-cell: 8.4 nTPM
naive B-cell: 6.8 nTPM
plasmacytoid DC: 6.1 nTPM
T-reg: 4.7 nTPM
myeloid DC: 4.5 nTPM

Brain region

choroid plexus: 38 nTPM
white matter: 34 nTPM
pons: 32 nTPM
midbrain: 32 nTPM
medulla oblongata: 30 nTPM
hypothalamus: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.61
gnomAD missense Z: 1.73
DepMap mean gene effect: -2.26
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDC16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDC16 as an antibody target. Whether an autoantibody or antibody against CDC16 could matter depends on whether native CDC16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDC16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDC16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...