Seroatlas · Human Serome Atlas

CDC26

Anaphase-promoting complex subunit CDC26

Also known as: ANAPC12, APC12, C9orf17, CDC26_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NHZ8
Gene: CDC26
Ensembl: ENSG00000176386
Chromosome: 9
Canonical length: 85 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

85 residues, UniProt reviewed canonical sequence.

>Q8NHZ8|CDC26
     1  MLRRKPTRLE LKLDDIEEFE NIRKDLETRK KQKEDVEVVG GSDGEGAIGL SSDPKSREQM
    61  INDRIGYKPQ PKPNNRSSQF GSLEF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDC26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 55 nTPM
heart muscle: 51 nTPM
liver: 50 nTPM
tongue: 49 nTPM
kidney: 49 nTPM
skeletal muscle: 46 nTPM

Single-cell type

cardiomyocytes: 59 nCPM
neutrophils: 31 nCPM
adipocytes: 16 nCPM
endometrial secretory cells: 15 nCPM
parietal cells: 14 nCPM
hepatic stellate cells: 13 nCPM

Immune cell

eosinophil: 275 nTPM
naive CD4 T-cell: 254 nTPM
T-reg: 242 nTPM
basophil: 240 nTPM
memory B-cell: 234 nTPM
memory CD4 T-cell: 223 nTPM

Brain region

choroid plexus: 31 nTPM
hypothalamus: 21 nTPM
medulla oblongata: 21 nTPM
spinal cord: 21 nTPM
white matter: 20 nTPM
cerebral cortex: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0.66
gnomAD missense Z: 0.73
DepMap mean gene effect: -0.77
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Anaphase-promoting complex, subunit CDC26
Anaphase-promoting complex APC subunit CDC26

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDC26 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDC26 as an antibody target. Whether an autoantibody or antibody against CDC26 could matter depends on whether native CDC26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDC26 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDC26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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