Seroatlas · Human Serome Atlas

MAD2L1BP

MAD2L1-binding protein

Also known as: CMT2, dJ261G23.1, KIAA0110, MD2BP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15013
Gene
MAD2L1BP
Ensembl
ENSG00000124688
Chromosome
6
Canonical length
274 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear membrane,Nucleoli

OverviewNCBI Gene

The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

274 residues, UniProt reviewed canonical sequence.

>Q15013|MAD2L1BP
     1  MAAPEAEVLS SAAVPDLEWY EKSEETHASQ IELLETSSTQ EPLNASEAFC PRDCMVPVVF
    61  PGPVSQEGCC QFTCELLKHI MYQRQQLPLP YEQLKHFYRK PSPQAEEMLK KKPRATTEVS
   121  SRKCQQALAE LESVLSHLED FFARTLVPRV LILLGGNALS PKEFYELDLS LLAPYSVDQS
   181  LSTAACLRRL FRAIFMADAF SELQAPPLMG TVVMAQGHRN CGEDWFRPKL NYRVPSRGHK
   241  LTVTLSCGRP SIRTTAWEDY IWFQAPVTFK GFRE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAD2L1BP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
51 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 51 nTPM
  • tongue: 42 nTPM
  • skeletal muscle: 28 nTPM
  • thymus: 27 nTPM
  • rectum: 26 nTPM
  • tonsil: 25 nTPM

Single-cell type

  • platelets: 99 nCPM
  • megakaryocytes: 56 nCPM
  • early spermatids: 56 nCPM
  • late spermatids: 51 nCPM
  • colonocytes: 44 nCPM
  • enterocytes: 44 nCPM

Immune cell

  • basophil: 106 nTPM
  • T-reg: 79 nTPM
  • naive CD4 T-cell: 57 nTPM
  • NK-cell: 56 nTPM
  • memory CD4 T-cell: 55 nTPM
  • memory B-cell: 53 nTPM

Brain region

  • choroid plexus: 15 nTPM
  • hypothalamus: 14 nTPM
  • cerebral cortex: 14 nTPM
  • hippocampal formation: 13 nTPM
  • pons: 13 nTPM
  • cerebellum: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.4
gnomAD pLI
0
gnomAD missense Z
0.54
DepMap mean gene effect
-0.53
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Mad1/Cdc20-bound-Mad2 binding protein
  • MAD2L1-binding domain-containing protein
  • Mad1 and Cdc20-bound-Mad2 binding

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAD2L1BP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAD2L1BP as an antibody target. Whether an autoantibody or antibody against MAD2L1BP could matter depends on whether native MAD2L1BP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAD2L1BP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAD2L1BP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MAD2L1BP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...