Seroatlas · Human Serome Atlas

ANAPC4

Anaphase-promoting complex subunit 4

Also known as: APC4, APC4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UJX5
Gene
ANAPC4
Ensembl
ENSG00000053900
Chromosome
4
Canonical length
808 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Canonical amino-acid sequenceUniProt

808 residues, UniProt reviewed canonical sequence.

>Q9UJX5|ANAPC4
     1  MLRFPTCFPS FRVVGEKQLP QEIIFLVWSP KRDLIALANT AGEVLLHRLA SFHRVWSFPP
    61  NENTGKEVTC LAWRPDGKLL AFALADTKKI VLCDVEKPES LHSFSVEAPV SCMHWMEVTV
   121  ESSVLTSFYN AEDESNLLLP KLPTLPKNYS NTSKIFSEEN SDEIIKLLGD VRLNILVLGG
   181  SSGFIELYAY GMFKIARVTG IAGTCLALCL SSDLKSLSVV TEVSTNGASE VSYFQLETNL
   241  LYSFLPEVTR MARKFTHISA LLQYINLSLT CMCEAWEEIL MQMDSRLTKF VQEKNTTTSV
   301  QDEFMHLLLW GKASAELQTL LMNQLTVKGL KKLGQSIESS YSSIQKLVIS HLQSGSESLL
   361  YHLSELKGMA SWKQKYEPLG LDAAGIEEAI TAVGSFILKA NELLQVIDSS MKNFKAFFRW
   421  LYVAMLRMTE DHVLPELNKM TQKDITFVAE FLTEHFNEAP DLYNRKGKYF NVERVGQYLK
   481  DEDDDLVSPP NTEGNQWYDF LQNSSHLKES PLLFPYYPRK SLHFVKRRME NIIDQCLQKP
   541  ADVIGKSMNQ AICIPLYRDT RSEDSTRRLF KFPFLWNNKT SNLHYLLFTI LEDSLYKMCI
   601  LRRHTDISQS VSNGLIAIKF GSFTYATTEK VRRSIYSCLD AQFYDDETVT VVLKDTVGRE
   661  GRDRLLVQLP LSLVYNSEDS AEYQFTGTYS TRLDEQCSAI PTRTMHFEKH WRLLESMKAQ
   721  YVAGNGFRKV SCVLSSNLRH VRVFEMDIDD EWELDESSDE EEEASNKPVK IKEEVLSESE
   781  AENQQAGAAA LAPEIVIKVE KLDPELDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANAPC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 33 nTPM
  • endometrium: 25 nTPM
  • cervix: 22 nTPM
  • seminal vesicle: 20 nTPM
  • lymph node: 19 nTPM
  • spleen: 19 nTPM

Single-cell type

  • endometrial ciliated cells: 687 nCPM
  • fallopian tube ciliated cells: 356 nCPM
  • epididymal efferent duct ciliated cells: 118 nCPM
  • respiratory ciliated cells: 110 nCPM
  • endometrial glandular cells: 101 nCPM
  • cytotrophoblasts: 95 nCPM

Immune cell

  • eosinophil: 15 nTPM
  • MAIT T-cell: 13 nTPM
  • non-classical monocyte: 13 nTPM
  • T-reg: 12 nTPM
  • memory CD8 T-cell: 11 nTPM
  • NK-cell: 10 nTPM

Brain region

  • white matter: 17 nTPM
  • cerebral cortex: 14 nTPM
  • choroid plexus: 14 nTPM
  • basal ganglia: 14 nTPM
  • thalamus: 14 nTPM
  • cerebellum: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0
gnomAD missense Z
2.5
DepMap mean gene effect
-1.26
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANAPC4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANAPC4 as an antibody target. Whether an autoantibody or antibody against ANAPC4 could matter depends on whether native ANAPC4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANAPC4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANAPC4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ANAPC4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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