Seroatlas · Human Serome Atlas

CDC23

Cell division cycle protein 23 homolog

Also known as: ANAPC8, APC8, CDC23_HUMAN, CUT23

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UJX2
Gene: CDC23
Ensembl: ENSG00000094880
Chromosome: 5
Canonical length: 597 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

597 residues, UniProt reviewed canonical sequence.

>Q9UJX2|CDC23
     1  MAASTSMVPV AVTAAVAPVL SINSDFSDLR EIKKQLLLIA GLTRERGLLH SSKWSAELAF
    61  SLPALPLAEL QPPPPITEED AQDMDAYTLA KAYFDVKEYD RAAHFLHGCN SKKAYFLYMY
   121  SRYLSGEKKK DDETVDSLGP LEKGQVKNEA LRELRVELSK KHQARELDGF GLYLYGVVLR
   181  KLDLVKEAID VFVEATHVLP LHWGAWLELC NLITDKEMLK FLSLPDTWMK EFFLAHIYTE
   241  LQLIEEALQK YQNLIDVGFS KSSYIVSQIA VAYHNIRDID KALSIFNELR KQDPYRIENM
   301  DTFSNLLYVR SMKSELSYLA HNLCEIDKYR VETCCVIGNY YSLRSQHEKA ALYFQRALKL
   361  NPRYLGAWTL MGHEYMEMKN TSAAIQAYRH AIEVNKRDYR AWYGLGQTYE ILKMPFYCLY
   421  YYRRAHQLRP NDSRMLVALG ECYEKLNQLV EAKKCYWRAY AVGDVEKMAL VKLAKLHEQL
   481  TESEQAAQCY IKYIQDIYSC GEIVEHLEES TAFRYLAQYY FKCKLWDEAS TCAQKCCAFN
   541  DTREEGKALL RQILQLRNQG ETPTTEVPAP FFLPASLSAN NTPTRRVSPL NLSSVTP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDC23 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

placenta: 25 nTPM
thymus: 19 nTPM
kidney: 19 nTPM
tonsil: 18 nTPM
parathyroid gland: 17 nTPM
liver: 17 nTPM

Single-cell type

oocytes: 83 nCPM
syncytiotrophoblasts: 51 nCPM
cytotrophoblasts: 42 nCPM
differentiating spermatogonia: 39 nCPM
erythrocyte progenitors: 37 nCPM
migrating cytotrophoblasts: 33 nCPM

Immune cell

basophil: 42 nTPM
NK-cell: 27 nTPM
naive CD4 T-cell: 24 nTPM
MAIT T-cell: 22 nTPM
eosinophil: 22 nTPM
naive CD8 T-cell: 21 nTPM

Brain region

cerebellum: 22 nTPM
cerebral cortex: 19 nTPM
white matter: 18 nTPM
hippocampal formation: 17 nTPM
basal ganglia: 17 nTPM
spinal cord: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.29
gnomAD pLI: 0.99
gnomAD missense Z: 2.78
DepMap mean gene effect: -2.19
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin-protein transferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Tetratricopeptide-like helical domain superfamily
Tetratricopeptide repeat
Tetratricopeptide repeat
TPR repeat
Cdc23
Anaphase promoting complex subunit 8 / Cdc23

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDC23 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDC23 as an antibody target. Whether an autoantibody or antibody against CDC23 could matter depends on whether native CDC23 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDC23 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDC23 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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