Seroatlas · Human Serome Atlas

UBE2S

Ubiquitin-conjugating enzyme E2 S

Also known as: E2-EPF, UBE2S_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16763
Gene: UBE2S
Ensembl: ENSG00000108106
Chromosome: 19
Canonical length: 222 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

222 residues, UniProt reviewed canonical sequence.

>Q16763|UBE2S
     1  MNSNVENLPP HIIRLVYKEV TTLTADPPDG IKVFPNEEDL TDLQVTIEGP EGTPYAGGLF
    61  RMKLLLGKDF PASPPKGYFL TKIFHPNVGA NGEICVNVLK RDWTAELGIR HVLLTIKCLL
   121  IHPNPESALN EEAGRLLLEN YEEYAARARL LTEIHGGAGG PSGRAEAGRA LASGTEASST
   181  DPGAPGGPGG AEGPMAKKHA GERDKKLAAK KKTDKKRALR RL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBE2S can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 146 nTPM

Expression across tissuesHPA

Tissue

testis: 146 nTPM
bone marrow: 109 nTPM
thymus: 45 nTPM
hippocampal formation: 35 nTPM
cerebral cortex: 35 nTPM
hypothalamus: 35 nTPM

Single-cell type

pdcs: 298 nCPM
breast secretory cells: 297 nCPM
differentiating spermatogonia: 213 nCPM
innate lymphoid cells: 195 nCPM
extravillous trophoblasts: 180 nCPM
late primary spermatocytes: 159 nCPM

Immune cell

memory B-cell: 2.5 nTPM
neutrophil: 2.4 nTPM
eosinophil: 1.3 nTPM
plasmacytoid DC: 1.3 nTPM
memory CD4 T-cell: 1 nTPM
memory CD8 T-cell: 1 nTPM

Brain region

hippocampal formation: 68 nTPM
hypothalamus: 66 nTPM
cerebral cortex: 65 nTPM
pons: 63 nTPM
white matter: 59 nTPM
medulla oblongata: 52 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.64
gnomAD pLI: 0.63
gnomAD missense Z: 0.96
DepMap mean gene effect: -0.38
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBE2S in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBE2S as an antibody target. Whether an autoantibody or antibody against UBE2S could matter depends on whether native UBE2S is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBE2S is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBE2S as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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