Seroatlas · Human Serome Atlas

NEUROD2

Neurogenic differentiation factor 2

Also known as: bHLHa1, NDF2_HUMAN, NDRF

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15784
Gene
NEUROD2
Ensembl
ENSG00000171532
Chromosome
17
Canonical length
382 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

382 residues, UniProt reviewed canonical sequence.

>Q15784|NEUROD2
     1  MLTRLFSEPG LLSDVPKFAS WGDGEDDEPR SDKGDAPPPP PPAPGPGAPG PARAAKPVPL
    61  RGEEGTEATL AEVKEEGELG GEEEEEEEEE EGLDEAEGER PKKRGPKKRK MTKARLERSK
   121  LRRQKANARE RNRMHDLNAA LDNLRKVVPC YSKTQKLSKI ETLRLAKNYI WALSEILRSG
   181  KRPDLVSYVQ TLCKGLSQPT TNLVAGCLQL NSRNFLTEQG ADGAGRFHGS GGPFAMHPYP
   241  YPCSRLAGAQ CQAAGGLGGG AAHALRTHGY CAAYETLYAA AGGGGASPDY NSSEYEGPLS
   301  PPLCLNGNFS LKQDSSPDHE KSYHYSMHYS ALPGSRPTGH GLVFGSSAVR GGVHSENLLS
   361  YDMHLHHDRG PMYEELNAFF HN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NEUROD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
99 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 99 nTPM
  • hippocampal formation: 41 nTPM
  • cerebral cortex: 29 nTPM
  • amygdala: 17 nTPM
  • spinal cord: 2.5 nTPM
  • midbrain: 1.4 nTPM

Single-cell type

  • brain excitatory neurons: 38 nCPM
  • neuroendocrine cells: 11 nCPM
  • retinal bipolar cells: 5.9 nCPM
  • retinal pigment epithelial cells: 4.3 nCPM
  • paneth cells: 3.9 nCPM
  • brain inhibitory neurons: 2.9 nCPM

Immune cell

  • basophil: 0.5 nTPM
  • MAIT T-cell: 0.1 nTPM
  • neutrophil: 0.1 nTPM
  • NK-cell: 0.1 nTPM
  • non-classical monocyte: 0.1 nTPM
  • plasmacytoid DC: 0.1 nTPM

Brain region

  • cerebral cortex: 81 nTPM
  • hippocampal formation: 80 nTPM
  • cerebellum: 80 nTPM
  • white matter: 45 nTPM
  • basal ganglia: 44 nTPM
  • pons: 42 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NEUROD2.

Disease | AllUniProt

Conditions NEUROD2 is implicated in, by any mechanism.

  • Developmental and epileptic encephalopathy 72 (DEE72) MIM:618374

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 110 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Developmental and epileptic encephalopathy, 72

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.33
gnomAD pLI
0.94
gnomAD missense Z
2.67
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NEUROD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NEUROD2 as an antibody target. Whether an autoantibody or antibody against NEUROD2 could matter depends on whether native NEUROD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NEUROD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NEUROD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NEUROD2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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