Seroatlas · Human Serome Atlas

BUB1B

Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Also known as: Bub1A, BUB1B_HUMAN, BUBR1, MAD3L, SSK1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60566
Gene: BUB1B
Ensembl: ENSG00000156970
Chromosome: 15
Canonical length: 1050 aa
Protein class: Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Subcellular location: Basal body,Cytosol

OverviewNCBI Gene

This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1050 residues, UniProt reviewed canonical sequence.

>O60566|BUB1B
     1  MAAVKKEGGA LSEAMSLEGD EWELSKENVQ PLRQGRIMST LQGALAQESA CNNTLQQQKR
    61  AFEYEIRFYT GNDPLDVWDR YISWTEQNYP QGGKESNMST LLERAVEALQ GEKRYYSDPR
   121  FLNLWLKLGR LCNEPLDMYS YLHNQGIGVS LAQFYISWAE EYEARENFRK ADAIFQEGIQ
   181  QKAEPLERLQ SQHRQFQARV SRQTLLALEK EEEEEVFESS VPQRSTLAEL KSKGKKTARA
   241  PIIRVGGALK APSQNRGLQN PFPQQMQNNS RITVFDENAD EASTAELSKP TVQPWIAPPM
   301  PRAKENELQA GPWNTGRSLE HRPRGNTASL IAVPAVLPSF TPYVEETARQ PVMTPCKIEP
   361  SINHILSTRK PGKEEGDPLQ RVQSHQQASE EKKEKMMYCK EKIYAGVGEF SFEEIRAEVF
   421  RKKLKEQREA ELLTSAEKRA EMQKQIEEME KKLKEIQTTQ QERTGDQQEE TMPTKETTKL
   481  QIASESQKIP GMTLSSSVCQ VNCCARETSL AENIWQEQPH SKGPSVPFSI FDEFLLSEKK
   541  NKSPPADPPR VLAQRRPLAV LKTSESITSN EDVSPDVCDE FTGIEPLSED AIITGFRNVT
   601  ICPNPEDTCD FARAARFVST PFHEIMSLKD LPSDPERLLP EEDLDVKTSE DQQTACGTIY
   661  SQTLSIKKLS PIIEDSREAT HSSGFSGSSA SVASTSSIKC LQIPEKLELT NETSENPTQS
   721  PWCSQYRRQL LKSLPELSAS AELCIEDRPM PKLEIEKEIE LGNEDYCIKR EYLICEDYKL
   781  FWVAPRNSAE LTVIKVSSQP VPWDFYINLK LKERLNEDFD HFCSCYQYQD GCIVWHQYIN
   841  CFTLQDLLQH SEYITHEITV LIIYNLLTIV EMLHKAEIVH GDLSPRCLIL RNRIHDPYDC
   901  NKNNQALKIV DFSYSVDLRV QLDVFTLSGF RTVQILEGQK ILANCSSPYQ VDLFGIADLA
   961  HLLLFKEHLQ VFWDGSFWKL SQNISELKDG ELWNKFFVRI LNANDEATVS VLGELAAEMN
  1021  GVFDTTFQSH LNKALWKVGK LTSPGALLFQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BUB1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

thymus: 33 nTPM
testis: 21 nTPM
bone marrow: 17 nTPM
tonsil: 14 nTPM
choroid plexus: 12 nTPM
lymph node: 12 nTPM

Single-cell type

monocyte progenitors: 80 nCPM
erythrocyte progenitors: 71 nCPM
early primary spermatocytes: 64 nCPM
neutrophil progenitors: 44 nCPM
choroid plexus epithelial cells: 40 nCPM
megakaryocyte progenitors: 39 nCPM

Immune cell

naive B-cell: 1.1 nTPM
plasmacytoid DC: 0.8 nTPM
memory B-cell: 0.6 nTPM
memory CD4 T-cell: 0.2 nTPM
myeloid DC: 0.2 nTPM
memory CD8 T-cell: 0.1 nTPM

Brain region

choroid plexus: 17 nTPM
cerebellum: 0.9 nTPM
thalamus: 0.9 nTPM
hippocampal formation: 0.8 nTPM
pons: 0.6 nTPM
basal ganglia: 0.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BUB1B.

Disease | AllUniProt

Conditions BUB1B is implicated in, by any mechanism.

Premature chromatid separation trait (PCS) MIM:176430
Mosaic variegated aneuploidy syndrome 1 (MVA1) MIM:257300

Disease | GeneticClinVar

83 pathogenic / likely-pathogenic of 2,416 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.58
gnomAD pLI: 0
gnomAD missense Z: 0.89
DepMap mean gene effect: -1.05
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BUB1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BUB1B as an antibody target. Whether an autoantibody or antibody against BUB1B could matter depends on whether native BUB1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BUB1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BUB1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...