Seroatlas · Human Serome Atlas

SPATC1

Speriolin

Also known as: MGC61633, SPATA15, SPERI_HUMAN, SPERIOLIN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q76KD6
Gene: SPATC1
Ensembl: ENSG00000186583
Chromosome: 8
Canonical length: 591 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable gamma-tubulin binding activity. Located in centrosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

591 residues, UniProt reviewed canonical sequence.

>Q76KD6|SPATC1
     1  MSLLTNYEGL RHQIERLVRE NEELKKLVRL IRENHELKSA IKTQAGGLGI SGFTSGLGEA
    61  TAGLSSRQNN GVFLPPSPAV ANERVLEEVG IMALAPLAEM LTSLQPSATP GSLMSPLTGT
   121  LSTLLSGPAP TSQSSPLTSF LTSPIAGPLT GTLASSLGLP STGTLTPSSL VAGPVAMSQS
   181  SPLIAPVMGT VAVSLSSPLL SSTATPPGVS QNLLANPMSN LVLPEAPRLR LAEPLRGGPT
   241  GPQSPACVVP TATTKVPLST EPPQSTQDPE PLSMAFAGAP LQTSTPIGAM GTPAPKTAFS
   301  FNTSDTQAQP SAAQEQVVPA SVPTSPTTSP TVTVLASAPA LAPQVATSYT PSSTTHIAQG
   361  APHPPSRMHN SPTQNLPVPH CPPHNAHSPP RTSSSPASVN DSRGPRTTEP STKSMMEVER
   421  KLAHRKTSKF PENPRESKQL AWERLVGEIA FQLDRRILSS IFPERVRLYG FTVSNIPEKI
   481  IQASLNPSDH KLDEKLCQRL TQRYVSVMNR LQSLGYNGRV HPALTEQLVN AYGILRERPE
   541  LAASEGGPYT VDFLQRVVVE TVHPGMLADA LLLLSCLSQL AHDDGKPMFI W

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

testis: 33 nTPM
bone marrow: 8 nTPM
spleen: 1.9 nTPM
appendix: 1.7 nTPM
lung: 0.8 nTPM
small intestine: 0.7 nTPM

Single-cell type

late spermatids: 674 nCPM
early primary spermatocytes: 312 nCPM
cardiomyocytes: 206 nCPM
early spermatids: 181 nCPM
retinal ganglion cells: 70 nCPM
neutrophils: 56 nCPM

Immune cell

naive B-cell: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM
memory B-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

pons: 5.3 nTPM
cerebellum: 4 nTPM
medulla oblongata: 3.3 nTPM
thalamus: 2.1 nTPM
cerebral cortex: 1.9 nTPM
midbrain: 1.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: -0.06
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SPATC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CDC20

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATC1 as an antibody target. Whether an autoantibody or antibody against SPATC1 could matter depends on whether native SPATC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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