Seroatlas · Human Serome Atlas

NINL

Ninein-like protein

Also known as: KIAA0980, NINL_HUMAN, NLP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2I6
Gene: NINL
Ensembl: ENSG00000101004
Chromosome: 20
Canonical length: 1382 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Microtubules,Cytokinetic bridge,Primary cilium,Cytosol

OverviewNCBI Gene

Predicted to enable calcium ion binding activity. Predicted to be involved in microtubule anchoring at centrosome. Located in centrosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1382 residues, UniProt reviewed canonical sequence.

>Q9Y2I6|NINL
     1  MDEEENHYVS QLREVYSSCD TTGTGFLDRQ ELTQLCLKLH LEQQLPVLLQ TLLGNDHFAR
    61  VNFEEFKEGF VAVLSSNAGV RPSDEDSSSL ESAASSAIPP KYVNGSKWYG RRSRPELCDA
   121  ATEARRVPEQ QTQASLKSHL WRSASLESVE SPKSDEEAES TKEAQNELFE AQGQLQTWDS
   181  EDFGSPQKSC SPSFDTPESQ IRGVWEELGV GSSGHLSEQE LAVVCQSVGL QGLEKEELED
   241  LFNKLDQDGD GKVSLEEFQL GLFSHEPALL LESSTRVKPS KAWSHYQVPE ESGCHTTTTS
   301  SLVSLCSSLR LFSSIDDGSG FAFPDQVLAM WTQEGIQNGR EILQSLDFSV DEKVNLLELT
   361  WALDNELMTV DSAVQQAALA CYHQELSYQQ GQVEQLARER DKARQDLERA EKRNLEFVKE
   421  MDDCHSTLEQ LTEKKIKHLE QGYRERLSLL RSEVEAEREL FWEQAHRQRA ALEWDVGRLQ
   481  AEEAGLREKL TLALKENSRL QKEIVEVVEK LSDSERLALK LQKDLEFVLK DKLEPQSAEL
   541  LAQEERFAAV LKEYELKCRD LQDRNDELQA ELEGLWARLP KNRHSPSWSP DGRRRQLPGL
   601  GPAGISFLGN SAPVSIETEL MMEQVKEHYQ DLRTQLETKV NYYEREIAAL KRNFEKERKD
   661  MEQARRREVS VLEGQKADLE ELHEKSQEVI WGLQEQLQDT ARGPEPEQMG LAPCCTQALC
   721  GLALRHHSHL QQIRREAEAE LSGELSGLGA LPARRDLTLE LEEPPQGPLP RGSQRSEQLE
   781  LERALKLQPC ASEKRAQMCV SLALEEEELE LARGKRVDGP SLEAEMQALP KDGLVAGSGQ
   841  EGTRGLLPLR PGCGERPLAW LAPGDGRESE EAAGAGPRRR QAQDTEATQS PAPAPAPASH
   901  GPSERWSRMQ PCGVDGDIVP KEPEPFGASA AGLEQPGARE LPLLGTERDA SQTQPRMWEP
   961  PLRPAASCRG QAERLQAIQE ERARSWSRGT QEQASEQQAR AEGALEPGCH KHSVEVARRG
  1021  SLPSHLQLAD PQGSWQEQLA APEEGETKIA LEREKDDMET KLLHLEDVVR ALEKHVDLRE
  1081  NDRLEFHRLS EENTLLKNDL GRVRQELEAA ESTHDAQRKE IEVLKKDKEK ACSEMEVLNR
  1141  QNQNYKDQLS QLNVRVLQLG QEASTHQAQN EEHRVTIQML TQSLEEVVRS GQQQSDQIQK
  1201  LRVELECLNQ EHQSLQLPWS ELTQTLEESQ DQVQGAHLRL RQAQAQHLQE VRLVPQDRVA
  1261  ELHRLLSLQG EQARRRLDAQ REEHEKQLKA TEERVEEAEM ILKNMEMLLQ EKVDKLKEQF
  1321  EKNTKSDLLL KELYVENAHL VRALQATEEK QRGAEKQSRL LEEKVRALNK LVSRIAPAAL
  1381  SV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NINL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

ovary: 18 nTPM
kidney: 18 nTPM
cerebellum: 17 nTPM
cervix: 10 nTPM
colon: 9.2 nTPM
thyroid gland: 9.2 nTPM

Single-cell type

proximal tubule cells: 297 nCPM
distal convoluted tubule cells: 222 nCPM
renal connecting tubule cells: 211 nCPM
renal collecting duct intercalated cells: 209 nCPM
loop of henle epithelial cells: 199 nCPM
sertoli cells: 191 nCPM

Immune cell

naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

choroid plexus: 9.4 nTPM
medulla oblongata: 7.2 nTPM
midbrain: 6.8 nTPM
hypothalamus: 6.3 nTPM
pons: 6.3 nTPM
cerebellum: 5.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: -0.98
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

microtubule anchoring at centrosome

Molecular functions

calcium ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NINL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NINL as an antibody target. Whether an autoantibody or antibody against NINL could matter depends on whether native NINL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NINL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NINL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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