RNH1

Protein identityUniProt · HPA

UniProt accession

P13489

Gene

RNH1

Ensembl

ENSG00000023191

Chromosome

11

Canonical length

461 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]

Canonical amino-acid sequenceUniProt

461 residues, UniProt reviewed canonical sequence.

>P13489|RNH1
     1  MSLDIQSLDI QCEELSDARW AELLPLLQQC QVVRLDDCGL TEARCKDISS ALRVNPALAE
    61  LNLRSNELGD VGVHCVLQGL QTPSCKIQKL SLQNCCLTGA GCGVLSSTLR TLPTLQELHL
   121  SDNLLGDAGL QLLCEGLLDP QCRLEKLQLE YCSLSAASCE PLASVLRAKP DFKELTVSNN
   181  DINEAGVRVL CQGLKDSPCQ LEALKLESCG VTSDNCRDLC GIVASKASLR ELALGSNKLG
   241  DVGMAELCPG LLHPSSRLRT LWIWECGITA KGCGDLCRVL RAKESLKELS LAGNELGDEG
   301  ARLLCETLLE PGCQLESLWV KSCSFTAACC SHFSSVLAQN RFLLELQISN NRLEDAGVRE
   361  LCQGLGQPGS VLRVLWLADC DVSDSSCSSL AATLLANHSL RELDLSNNCL GDAGILQLVE
   421  SVRQPGCLLE QLVLYDIYWS EEMEDRLQAL EKDKPSLRVI S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.21

Highest tissue expression

247 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RNH1.

Disease | AllUniProt

Conditions RNH1 is implicated in, by any mechanism.

• Encephalitis, acute, infection-induced, 12 (IIAE12) MIM:620461

Disease | ImmuneIEDB

Conditions an epitope on RNH1 was assayed in.

• 1-chloro-2 T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.22

gnomAD pLI

0

gnomAD missense Z

-0.09

DepMap mean gene effect

-0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell migration
• mRNA catabolic process
• regulation of angiogenesis
• regulation of Arp2/3 complex-mediated actin nucleation
• tRNA stabilization

Molecular functions

• ribonuclease inhibitor activity

Cellular components

• angiogenin-PRI complex
• cytoplasm
• cytosol
• extracellular exosome
• lamellipodium
• nucleoplasm
• nucleus
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Leucine-rich repeat
• Leucine-rich repeat, cysteine-containing subtype
• Leucine-rich repeat domain superfamily
• NLRP family, innate immunity and inflammation regulators
• Leucine Rich repeat
• Ribonuclease inhibitor, leucine rich repeat cap
• Capping Ribonuclease inhibitor Leucine Rich Repeat

KeywordsUniProt

• Acetylation
• Cytoplasm
• Leucine-rich repeat
• Nucleus
• Phosphoprotein
• Repeat

InteractionsUniProt · HPA

Protein binding partners of RNH1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ANG
• CDC20
• RNASE1
• SDCBP