Seroatlas · Human Serome Atlas

USP22

Ubiquitin carboxyl-terminal hydrolase 22

Also known as: KIAA1063, UBP22_HUMAN, USP3L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UPT9
Gene
USP22
Ensembl
ENSG00000124422
Chromosome
17
Canonical length
525 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nuclear speckles

OverviewNCBI Gene

Enables deubiquitinase activity; enzyme binding activity; and transcription coactivator activity. Contributes to histone H4 acetyltransferase activity. Involved in several processes, including G2/M transition of mitotic cell cycle; protein deubiquitination; and regulation of gene expression. Part of SAGA complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

525 residues, UniProt reviewed canonical sequence.

>Q9UPT9|USP22
     1  MVSRPEPEGE AMDAELAVAP PGCSHLGSFK VDNWKQNLRA IYQCFVWSGT AEARKRKAKS
    61  CICHVCGVHL NRLHSCLYCV FFGCFTKKHI HEHAKAKRHN LAIDLMYGGI YCFLCQDYIY
   121  DKDMEIIAKE EQRKAWKMQG VGEKFSTWEP TKRELELLKH NPKRRKITSN CTIGLRGLIN
   181  LGNTCFMNCI VQALTHTPLL RDFFLSDRHR CEMQSPSSCL VCEMSSLFQE FYSGHRSPHI
   241  PYKLLHLVWT HARHLAGYEQ QDAHEFLIAA LDVLHRHCKG DDNGKKANNP NHCNCIIDQI
   301  FTGGLQSDVT CQVCHGVSTT IDPFWDISLD LPGSSTPFWP LSPGSEGNVV NGESHVSGTT
   361  TLTDCLRRFT RPEHLGSSAK IKCSGCHSYQ ESTKQLTMKK LPIVACFHLK RFEHSAKLRR
   421  KITTYVSFPL ELDMTPFMAS SKESRMNGQY QQPTDSLNND NKYSLFAVVN HQGTLESGHY
   481  TSFIRQHKDQ WFKCDDAIIT KASIKDVLDS EGYLLFYHKQ FLEYE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against USP22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
119 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 119 nTPM
  • skeletal muscle: 103 nTPM
  • hypothalamus: 86 nTPM
  • cerebral cortex: 86 nTPM
  • basal ganglia: 82 nTPM
  • tongue: 76 nTPM

Single-cell type

  • retinal ganglion cells: 209 nCPM
  • cone photoreceptor cells: 170 nCPM
  • retinal horizontal cells: 160 nCPM
  • megakaryocyte-erythroid progenitors: 158 nCPM
  • megakaryocyte progenitors: 142 nCPM
  • pituicytes/fscs: 130 nCPM

Immune cell

  • naive CD4 T-cell: 11 nTPM
  • naive CD8 T-cell: 10 nTPM
  • eosinophil: 10 nTPM
  • naive B-cell: 9.9 nTPM
  • neutrophil: 9.9 nTPM
  • non-classical monocyte: 9.7 nTPM

Brain region

  • hypothalamus: 266 nTPM
  • basal ganglia: 207 nTPM
  • cerebral cortex: 207 nTPM
  • pons: 199 nTPM
  • hippocampal formation: 192 nTPM
  • midbrain: 179 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.42
gnomAD pLI
0.55
gnomAD missense Z
3.56
DepMap mean gene effect
0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of USP22 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads USP22 as an antibody target. Whether an autoantibody or antibody against USP22 could matter depends on whether native USP22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

USP22 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label USP22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/USP22. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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