Seroatlas · Human Serome Atlas

ABI2

Abl interactor 2

Also known as: ABI-2, ABI2_HUMAN, ABI2B, AblBP3, AIP-1, argBPIA, SSH3BP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NYB9
Gene
ABI2
Ensembl
ENSG00000138443
Chromosome
2
Canonical length
513 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

Enables several functions, including SH3 domain binding activity; proline-rich region binding activity; and ubiquitin protein ligase binding activity. Contributes to small GTPase binding activity. Involved in several processes, including Rac protein signal transduction; positive regulation of cellular component organization; and zonula adherens assembly. Acts upstream of or within peptidyl-tyrosine phosphorylation. Located in several cellular components, including actin filament; filopodium tip; and lamellipodium. Part of SCAR complex. Is active in adherens junction. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

513 residues, UniProt reviewed canonical sequence.

>Q9NYB9|ABI2
     1  MAELQMLLEE EIPGGRRALF DSYTNLERVA DYCENNYIQS ADKQRALEET KAYTTQSLAS
    61  VAYLINTLAN NVLQMLDIQA SQLRRMESSI NHISQTVDIH KEKVARREIG ILTTNKNTSR
   121  THKIIAPANL ERPVRYIRKP IDYTILDDIG HGVKWLLRFK VSTQNMKMGG LPRTTPPTQK
   181  PPSPPMSGKG TLGRHSPYRT LEPVRPPVVP NDYVPSPTRN MAPSQQSPVR TASVNQRNRT
   241  YSSSGSSGGS HPSSRSSSRE NSGSGSVGVP IAVPTPSPPS VFPAPAGSAG TPPLPATSAS
   301  APAPLVPATV PSSTAPNAAA GGAPNLADGF TSPTPPVVSS TPPTGHPVQF YSMNRPASRH
   361  TPPTIGGSLP YRRPPSITSQ TSLQNQMNGG PFYSQNPVSD TPPPPPPVEE PVFDESPPPP
   421  PPPEDYEEEE AAVVEYSDPY AEEDPPWAPR SYLEKVVAIY DYTKDKEDEL SFQEGAIIYV
   481  IKKNDDGWYE GVMNGVTGLF PGNYVESIMH YSE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABI2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
46 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 46 nTPM
  • basal ganglia: 45 nTPM
  • amygdala: 35 nTPM
  • hippocampal formation: 31 nTPM
  • heart muscle: 31 nTPM
  • hypothalamus: 28 nTPM

Single-cell type

  • bergmann glia: 466 nCPM
  • lactotrophs: 313 nCPM
  • brain inhibitory neurons: 268 nCPM
  • thyrotrophs: 263 nCPM
  • cardiomyocytes: 262 nCPM
  • brain excitatory neurons: 247 nCPM

Immune cell

  • plasmacytoid DC: 13 nTPM
  • naive CD4 T-cell: 4.4 nTPM
  • T-reg: 4.4 nTPM
  • myeloid DC: 4 nTPM
  • naive CD8 T-cell: 3.9 nTPM
  • NK-cell: 3.9 nTPM

Brain region

  • basal ganglia: 132 nTPM
  • cerebral cortex: 127 nTPM
  • hypothalamus: 119 nTPM
  • hippocampal formation: 116 nTPM
  • amygdala: 105 nTPM
  • thalamus: 97 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ABI2.

Disease | ImmuneIEDB

Conditions an epitope on ABI2 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0.43
gnomAD missense Z
2.25
DepMap mean gene effect
0.13
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ABI2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABI2 as an antibody target. Whether an autoantibody or antibody against ABI2 could matter depends on whether native ABI2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABI2 is annotated at the cell surface, where native ABI2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ABI2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ABI2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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