Seroatlas · Human Serome Atlas

TLE5

TLE family member 5

Also known as: AES, GRG5, TLE5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q08117
Gene: TLE5
Ensembl: ENSG00000104964
Chromosome: 19
Canonical length: 197 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm
Quaternary structure: Homooligomer

OverviewNCBI Gene

The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

197 residues, UniProt reviewed canonical sequence.

>Q08117|TLE5
     1  MMFPQSRHSG SSHLPQQLKF TTSDSCDRIK DEFQLLQAQY HSLKLECDKL ASEKSEMQRH
    61  YVMYYEMSYG LNIEMHKQAE IVKRLNGICA QVLPYLSQEH QQQVLGAIER AKQVTAPELN
   121  SIIRQQLQAH QLSQLQALAL PLTPLPVGLQ PPSLPAVSAG TGLLSLSALG SQAHLSKEDK
   181  NGHDGDTHQE DDGEKSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TLE5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 594 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 594 nTPM
cerebellum: 589 nTPM
amygdala: 501 nTPM
skeletal muscle: 476 nTPM
heart muscle: 464 nTPM
hippocampal formation: 421 nTPM

Single-cell type

extravillous trophoblasts: 538 nCPM
prostatic club cells: 371 nCPM
salivary duct cells: 345 nCPM
prostatic hillock cells: 318 nCPM
respiratory secretory cells: 308 nCPM
smooth muscle cells: 306 nCPM

Immune cell

T-reg: 243 nTPM
naive CD4 T-cell: 222 nTPM
memory CD4 T-cell: 170 nTPM
naive CD8 T-cell: 150 nTPM
memory CD8 T-cell: 135 nTPM
gdT-cell: 131 nTPM

Brain region

cerebral cortex: 441 nTPM
pons: 390 nTPM
thalamus: 383 nTPM
cerebellum: 371 nTPM
hypothalamus: 349 nTPM
amygdala: 339 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.36
gnomAD pLI: 0.94
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TLE5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TLE5 as an antibody target. Whether an autoantibody or antibody against TLE5 could matter depends on whether native TLE5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TLE5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TLE5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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