Seroatlas · Human Serome Atlas

LMO2

Rhombotin-2

Also known as: RBTN2, RBTN2_HUMAN, RBTNL1, RHOM2, TTG2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P25791
Gene
LMO2
Ensembl
ENSG00000135363
Chromosome
11
Canonical length
158 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008]

Canonical amino-acid sequenceUniProt

158 residues, UniProt reviewed canonical sequence.

>P25791|LMO2
     1  MSSAIERKSL DPSEEPVDEV LQIPPSLLTC GGCQQNIGDR YFLKAIDQYW HEDCLSCDLC
    61  GCRLGEVGRR LYYKLGRKLC RRDYLRLFGQ DGLCASCDKR IRAYEMTMRV KDKVYHLECF
   121  KCAACQKHFC VGDRYLLINS DIVCEQDIYE WTKINGMI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LMO2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 26 nTPM
  • skeletal muscle: 22 nTPM
  • lymph node: 18 nTPM
  • spleen: 18 nTPM
  • basal ganglia: 18 nTPM
  • hippocampal formation: 17 nTPM

Single-cell type

  • erythrocyte progenitors: 409 nCPM
  • megakaryocyte-erythroid progenitors: 385 nCPM
  • lymphatic endothelial cells: 262 nCPM
  • thymic myoid cells: 237 nCPM
  • ependymal cells: 222 nCPM
  • megakaryocyte progenitors: 214 nCPM

Immune cell

  • myeloid DC: 1.9 nTPM
  • non-classical monocyte: 1.7 nTPM
  • eosinophil: 1.5 nTPM
  • intermediate monocyte: 1.4 nTPM
  • neutrophil: 0.7 nTPM
  • basophil: 0.6 nTPM

Brain region

  • medulla oblongata: 37 nTPM
  • thalamus: 36 nTPM
  • spinal cord: 35 nTPM
  • pons: 34 nTPM
  • midbrain: 29 nTPM
  • hypothalamus: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.03
gnomAD pLI
0.16
gnomAD missense Z
1.34
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LMO2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LMO2 as an antibody target. Whether an autoantibody or antibody against LMO2 could matter depends on whether native LMO2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LMO2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LMO2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LMO2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...