Seroatlas · Human Serome Atlas

DTNB

Dystrobrevin beta

Also known as: DTNB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60941
Gene
DTNB
Ensembl
ENSG00000138101
Chromosome
2
Canonical length
627 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Golgi apparatus

OverviewNCBI Gene

This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

627 residues, UniProt reviewed canonical sequence.

>O60941|DTNB
     1  MIEESGNKRK TMAEKRQLFI EMRAQNFDVI RLSTYRTACK LRFVQKRCNL HLVDIWNMIE
    61  AFRDNGLNTL DHTTEISVSR LETVISSIYY QLNKRLPSTH QISVEQSISL LLNFMIAAYD
   121  SEGRGKLTVF SVKAMLATMC GGKMLDKLRY VFSQMSDSNG LMIFSKFDQF LKEVLKLPTA
   181  VFEGPSFGYT EHSVRTCFPQ QRKIMLNMFL DTMMADPPPQ CLVWLPLMHR LAHVENVFHP
   241  VECSYCRCES MMGFRYRCQQ CHNYQLCQNC FWRGHAGGPH SNQHQMKEHS SWKSPAKKLS
   301  HAISKSLGCV PTREPPHPVF PEQPEKPLDL AHIVPPRPLT NMNDTMVSHM SSGVPTPTKR
   361  LQYSQDIPSH LADEHALIAS YVARLQHCAR VLDSPSRLDE EHRLIARYAA RLAAEAGNVT
   421  RPPTDLSFNF DANKQQRQLI AELENKNREI LQEIQRLRLE HEQASQPTPE KAQQNPTLLA
   481  ELRLLRQRKD ELEQRMSALQ ESRRELMVQL EELMKLLKEE EQKQAAQATG SPHTSPTHGG
   541  GRPMPMPVRS TSAGSTPTHC PQDSLSGVGG DVQEAFAQGT RRNLRNDLLV AADSITNTMS
   601  SLVKELHSAE EGAEEEEEKM QNGKDRG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DTNB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 34 nTPM
  • cerebral cortex: 24 nTPM
  • basal ganglia: 18 nTPM
  • hippocampal formation: 18 nTPM
  • amygdala: 16 nTPM
  • spinal cord: 16 nTPM

Single-cell type

  • salivary acinar cells: 663 nCPM
  • lacrimal acinar cells: 628 nCPM
  • hofbauer cells: 451 nCPM
  • salivary myoepithelial cells: 347 nCPM
  • oligodendrocytes: 342 nCPM
  • salivary basal cells: 333 nCPM

Immune cell

  • naive B-cell: 5.8 nTPM
  • eosinophil: 5.7 nTPM
  • T-reg: 5.2 nTPM
  • memory CD4 T-cell: 5 nTPM
  • naive CD4 T-cell: 5 nTPM
  • MAIT T-cell: 4.4 nTPM

Brain region

  • hippocampal formation: 44 nTPM
  • cerebral cortex: 44 nTPM
  • amygdala: 34 nTPM
  • basal ganglia: 32 nTPM
  • white matter: 29 nTPM
  • pons: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.79
gnomAD pLI
0
gnomAD missense Z
0.57
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DTNB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DTNB as an antibody target. Whether an autoantibody or antibody against DTNB could matter depends on whether native DTNB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DTNB is annotated at the cell surface, where native DTNB is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DTNB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DTNB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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