Seroatlas · Human Serome Atlas

IFT20

Intraflagellar transport protein 20 homolog

Also known as: IFT20_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IY31
Gene
IFT20
Ensembl
ENSG00000109083
Chromosome
17
Canonical length
132 aa
Protein class
Predicted intracellular proteins
Subcellular location
Microtubules,Mitotic spindle,Primary cilium,Basal body,Flagellar centriole,Mid piece,Principal piece,End piece

OverviewNCBI Gene

This gene encodes a intraflagellar transport protein important for intracellular transport. The encoded protein forms part of a complex involved in trafficking of proteins from the Golgi body, including recycling of immune signalling components (Finetti et al., PubMed: 19855387). This gene is part of a complex set of sense-antisense loci that may be co-regulated. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 14.[provided by RefSeq, Jun 2012]

Canonical amino-acid sequenceUniProt

132 residues, UniProt reviewed canonical sequence.

>Q8IY31|IFT20
     1  MAKDILGEAG LHFDELNKLR VLDPEVTQQT IELKEECKDF VDKIGQFQKI VGGLIELVDQ
    61  LAKEAENEKM KAIGARNLLK SIAKQREAQQ QQLQALIAEK KMQLERYRVE YEALCKVEAE
   121  QNEFIDQFIF QK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFT20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
110 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 110 nTPM
  • bone marrow: 73 nTPM
  • testis: 46 nTPM
  • pituitary gland: 43 nTPM
  • stomach: 40 nTPM
  • salivary gland: 39 nTPM

Single-cell type

  • early spermatids: 255 nCPM
  • late primary spermatocytes: 245 nCPM
  • breast lactating cells: 213 nCPM
  • gastric chief cells: 130 nCPM
  • early primary spermatocytes: 121 nCPM
  • epididymal principal cells: 119 nCPM

Immune cell

  • myeloid DC: 78 nTPM
  • neutrophil: 72 nTPM
  • classical monocyte: 68 nTPM
  • plasmacytoid DC: 56 nTPM
  • basophil: 54 nTPM
  • total PBMC: 54 nTPM

Brain region

  • choroid plexus: 17 nTPM
  • hypothalamus: 16 nTPM
  • white matter: 15 nTPM
  • medulla oblongata: 15 nTPM
  • midbrain: 14 nTPM
  • spinal cord: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.85
gnomAD pLI
0.1
gnomAD missense Z
0.12
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Intraflagellar transport protein 20
  • Intraflagellar transport complex B, subunit 20

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IFT20 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFT20 as an antibody target. Whether an autoantibody or antibody against IFT20 could matter depends on whether native IFT20 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFT20 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IFT20 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IFT20. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...