Seroatlas · Human Serome Atlas

PRR16

Protein Largen

Also known as: DSC54, LARGN_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q569H4
Gene: PRR16
Ensembl: ENSG00000184838
Chromosome: 5
Canonical length: 304 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Midbody,Cytosol

OverviewNCBI Gene

Involved in positive regulation of cell size and positive regulation of translation. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

304 residues, UniProt reviewed canonical sequence.

>Q569H4|PRR16
     1  MSAKSKGNPS SSCPAEGPPA ASKTKVKEQI KIIVEDLELV LGDLKDVAKE LKEVVDQIDT
    61  LTSDLQLEDE MTDSSKTDTL NSSSSGTTAS SLEKIKVQAN APLIKPPAHP SAILTVLRKP
   121  NPPPPPPRLT PVKCEDPKRV VPTANPVKTN GTLLRNGGLP GGPNKIPNGD ICCIPNSNLD
   181  KAPVQLLMHR PEKDRCPQAG PRERVRFNEK VQYHGYCPDC DTRYNIKNRE VHLHSEPVHP
   241  PGKIPHQGPP LPPTPHLPPF PLENGGMGIS HSNSFPPIRP ATVPPPTAPK PQKTILRKST
   301  TTTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRR16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

tongue: 28 nTPM
skeletal muscle: 25 nTPM
blood vessel: 19 nTPM
cervix: 14 nTPM
endometrium: 12 nTPM
heart muscle: 12 nTPM

Single-cell type

cone photoreceptor cells: 569 nCPM
myonuclei: 413 nCPM
thymic myoid cells: 377 nCPM
endometrial stromal cells: 352 nCPM
brain excitatory neurons: 250 nCPM
brain inhibitory neurons: 248 nCPM

Immune cell

classical monocyte: 0.7 nTPM
intermediate monocyte: 0.4 nTPM
myeloid DC: 0.3 nTPM
non-classical monocyte: 0.3 nTPM
total PBMC: 0.3 nTPM
basophil: 0.1 nTPM

Brain region

cerebellum: 18 nTPM
hypothalamus: 16 nTPM
cerebral cortex: 13 nTPM
pons: 13 nTPM
basal ganglia: 9.8 nTPM
thalamus: 9.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0.08
gnomAD missense Z: -0.8
DepMap mean gene effect: -0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

InteractionsUniProt · HPA

Protein binding partners of PRR16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ABI2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRR16 as an antibody target. Whether an autoantibody or antibody against PRR16 could matter depends on whether native PRR16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRR16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRR16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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