ADAM19

Protein identityUniProt · HPA

UniProt accession

Q9H013

Gene

ADAM19

Ensembl

ENSG00000135074

Chromosome

5

Canonical length

955 aa

Protein class

Plasma proteins, Predicted membrane proteins

Subcellular location

Vesicles

OverviewNCBI Gene

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. [provided by RefSeq, May 2013]

Canonical amino-acid sequenceUniProt

955 residues, UniProt reviewed canonical sequence.

>Q9H013|ADAM19
     1  MPGGAGAARL CLLAFALQPL RPRAAREPGW TRGSEEGSPK LQHELIIPQW KTSESPVREK
    61  HPLKAELRVM AEGRELILDL EKNEQLFAPS YTETHYTSSG NPQTTTRKLE DHCFYHGTVR
   121  ETELSSVTLS TCRGIRGLIT VSSNLSYVIE PLPDSKGQHL IYRSEHLKPP PGNCGFEHSK
   181  PTTRDWALQF TQQTKKRPRR MKREDLNSMK YVELYLVADY LEFQKNRRDQ DATKHKLIEI
   241  ANYVDKFYRS LNIRIALVGL EVWTHGNMCE VSENPYSTLW SFLSWRRKLL AQKYHDNAQL
   301  ITGMSFHGTT IGLAPLMAMC SVYQSGGVNM DHSENAIGVA ATMAHEMGHN FGMTHDSADC
   361  CSASAADGGC IMAAATGHPF PKVFNGCNRR ELDRYLQSGG GMCLSNMPDT RMLYGGRRCG
   421  NGYLEDGEEC DCGEEEECNN PCCNASNCTL RPGAECAHGS CCHQCKLLAP GTLCREQARQ
   481  CDLPEFCTGK SPHCPTNFYQ MDGTPCEGGQ AYCYNGMCLT YQEQCQQLWG PGARPAPDLC
   541  FEKVNVAGDT FGNCGKDMNG EHRKCNMRDA KCGKIQCQSS EARPLESNAV PIDTTIIMNG
   601  RQIQCRGTHV YRGPEEEGDM LDPGLVMTGT KCGYNHICFE GQCRNTSFFE TEGCGKKCNG
   661  HGVCNNNQNC HCLPGWAPPF CNTPGHGGSI DSGPMPPESV GPVVAGVLVA ILVLAVLMLM
   721  YYCCRQNNKL GQLKPSALPS KLRQQFSCPF RVSQNSGTGH ANPTFKLQTP QGKRKVINTP
   781  EILRKPSQPP PRPPPDYLRG GSPPAPLPAH LSRAARNSPG PGSQIERTES SRRPPPSRPI
   841  PPAPNCIVSQ DFSRPRPPQK ALPANPVPGR RSLPRPGGAS PLRPPGAGPQ QSRPLAALAP
   901  KVSPREALKV KAGTRGLQGG RCRVEKTKQF MLLVVWTELP EQKPRAKHSC FLVPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADAM19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.39

Highest tissue expression

28 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.5

gnomAD pLI

0

gnomAD missense Z

1.88

DepMap mean gene effect

0.1

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• amyloid precursor protein catabolic process
• membrane protein ectodomain proteolysis
• placenta development
• positive regulation of cell-cell adhesion mediated by cadherin
• positive regulation of gene expression
• protein processing

Molecular functions

• metal ion binding
• metalloendopeptidase activity
• metalloendopeptidase activity involved in amyloid precursor protein catabolic process
• SH3 domain binding

Cellular components

• extracellular matrix
• nucleus
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• EGF-like domain
• Peptidase M12B, ADAM/reprolysin
• Disintegrin domain
• Peptidase M12B, propeptide
• ADAM, cysteine-rich domain
• Disintegrin, conserved site
• Metallopeptidase, catalytic domain superfamily
• Reprolysin domain, adamalysin-type
• Disintegrin domain superfamily
• Disintegrin
• Reprolysin (M12B) family zinc metalloprotease
• Reprolysin family propeptide
• ADAM cysteine-rich

KeywordsUniProt

• Disulfide bond
• EGF-like domain
• Glycoprotein
• Hydrolase
• Membrane
• Metal-binding
• Metalloprotease
• Protease
• SH3-binding
• Signal
• Transmembrane
• Transmembrane helix
• Zinc
• Zymogen

InteractionsUniProt · HPA

Protein binding partners of ADAM19 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SH3PXD2A
• ABI2