HOMER3

Protein identityUniProt · HPA

UniProt accession

Q9NSC5

Gene

HOMER3

Ensembl

ENSG00000051128

Chromosome

19

Canonical length

361 aa

Protein class

Predicted intracellular proteins

Subcellular location

Plasma membrane,Cytosol,Cytoplasmic bodies

OverviewNCBI Gene

This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

Canonical amino-acid sequenceUniProt

361 residues, UniProt reviewed canonical sequence.

>Q9NSC5|HOMER3
     1  MSTAREQPIF STRAHVFQID PATKRNWIPA GKHALTVSYF YDATRNVYRI ISIGGAKAII
    61  NSTVTPNMTF TKTSQKFGQW ADSRANTVYG LGFASEQHLT QFAEKFQEVK EAARLAREKS
   121  QDGGELTSPA LGLASHQVPP SPLVSANGPG EEKLFRSQSA DAPGPTERER LKKMLSEGSV
   181  GEVQWEAEFF ALQDSNNKLA GALREANAAA AQWRQQLEAQ RAEAERLRQR VAELEAQAAS
   241  EVTPTGEKEG LGQGQSLEQL EALVQTKDQE IQTLKSQTGG PREALEAAER EETQQKVQDL
   301  ETRNAELEHQ LRAMERSLEE ARAERERARA EVGRAAQLLD VSLFELSELR EGLARLAEAA
   361  P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HOMER3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.47

Highest tissue expression

118 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HOMER3.

Disease | AutoantibodyPubMed

Conditions in which antibodies against HOMER3 are reported. Each links to that disease's full target list.

• Cerebellar Ataxia 6

ReferencesPubMed · IEDB

Publications for HOMER3 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.34

gnomAD pLI

0.95

gnomAD missense Z

1.19

DepMap mean gene effect

-0.14

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• G protein-coupled glutamate receptor signaling pathway
• negative regulation of calcineurin-NFAT signaling cascade
• negative regulation of interleukin-2 production
• protein targeting
• regulation of store-operated calcium entry
• regulation of synaptic transmission, glutamatergic

Molecular functions

• G protein-coupled glutamate receptor binding
• identical protein binding
• protein domain specific binding

Cellular components

• basal part of cell
• cytoplasm
• cytosol
• dendrite
• glutamatergic synapse
• plasma membrane
• postsynaptic density

Protein domainsUniProt · Pfam · InterPro

• WH1/EVH1 domain
• PH-like domain superfamily
• Homer, EVH1 domain
• Homer family
• WH1 domain

KeywordsUniProt

• Coiled coil
• Cytoplasm
• Phosphoprotein
• Synapse

InteractionsUniProt · HPA

Protein binding partners of HOMER3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• NFATC1
• NFATC2
• NFATC4
• SHANK1
• SHANK3
• ABI2
• DYNLL2
• FBXO28
• FRYL
• HOMER1
• WBP2