Seroatlas · Human Serome Atlas

CCDC102B

Coiled-coil domain-containing protein 102B

Also known as: ACY1L, AN, C102B_HUMAN, C18orf14, FLJ23594, HsT1731

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q68D86
Gene: CCDC102B
Ensembl: ENSG00000150636
Chromosome: 18
Canonical length: 513 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables protein serine/threonine kinase binding activity. Involved in centriole-centriole cohesion. Located in centriole. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

513 residues, UniProt reviewed canonical sequence.

>Q68D86|CCDC102B
     1  MNLDSIHRLI EETQIFQMQQ SSIKSRGDMV APASPPRDTC NTCFPLHGLQ SHAAHNFCAH
    61  SYNTNKWDIC EELRLRELEE VKARAAQMEK TMRWWSDCTA NWREKWSKVR AERNSAREEG
   121  RQLRIKLEMA MKELSTLKKK QSLPPQKEAL EAKVTQDLKL PGFVEESCEH TDQFQLSSQM
   181  HESIREYLVK RQFSTKEDTN NKEQGVVIDS LKLSEEMKPN LDGVDLFNNG GSGNGETKTG
   241  LRLKAINLPL ENEVTEISAL QVHLDEFQKI LWKEREMRTA LEKEIERLES ALSLWKWKYE
   301  ELKESKPKNV KEFDILLGQH NDEMQELSGN IKEESKSQNS KDRVICELRA ELERLQAENT
   361  SEWDKREILE REKQGLEREN RRLKIQVKEM EELLDKKNRL SANSQSPDFK MSQIDLQEKN
   421  QELLNLQHAY YKLNRQYQAN IAELTHANNR VDQNEAEVKK LRLRVEELKQ GLNQKEDELD
   481  DSLNQIRKLQ RSLDEEKERN ENLETELRHL QNW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC102B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

placenta: 27 nTPM
lung: 13 nTPM
gallbladder: 13 nTPM
urinary bladder: 9.9 nTPM
lymph node: 8 nTPM
adipose tissue: 6.7 nTPM

Single-cell type

pericytes: 446 nCPM
fibro-adipogenic progenitors: 192 nCPM
early spermatids: 132 nCPM
lymphatic endothelial cells: 127 nCPM
late spermatids: 103 nCPM
fibroblasts: 101 nCPM

Immune cell

plasmacytoid DC: 9.1 nTPM
naive CD4 T-cell: 1.8 nTPM
gdT-cell: 1.1 nTPM
naive CD8 T-cell: 1.1 nTPM
NK-cell: 1 nTPM
MAIT T-cell: 0.9 nTPM

Brain region

white matter: 12 nTPM
cerebral cortex: 12 nTPM
pons: 12 nTPM
medulla oblongata: 11 nTPM
thalamus: 10 nTPM
hypothalamus: 9.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0
gnomAD missense Z: -0.55
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC102B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC102B as an antibody target. Whether an autoantibody or antibody against CCDC102B could matter depends on whether native CCDC102B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC102B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC102B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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