Seroatlas · Human Serome Atlas

STAM2

Signal transducing adapter molecule 2

Also known as: Hbp, STAM2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75886
Gene
STAM2
Ensembl
ENSG00000115145
Chromosome
2
Canonical length
525 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

525 residues, UniProt reviewed canonical sequence.

>O75886|STAM2
     1  MPLFTANPFE QDVEKATNEY NTTEDWSLIM DICDKVGSTP NGAKDCLKAI MKRVNHKVPH
    61  VALQALTLLG ACVANCGKIF HLEVCSRDFA TEVRAVIKNK AHPKVCEKLK SLMVEWSEEF
   121  QKDPQFSLIS ATIKSMKEEG ITFPPAGSQT VSAAAKNGTS SNKNKEDEDI AKAIELSLQE
   181  QKQQHTETKS LYPSSEIQLN NKVARKVRAL YDFEAVEDNE LTFKHGEIII VLDDSDANWW
   241  KGENHRGIGL FPSNFVTTNL NIETEAAAVD KLNVIDDDVE EIKKSEPEPV YIDEDKMDRA
   301  LQVLQSIDPT DSKPDSQDLL DLEDICQQMG PMIDEKLEEI DRKHSELSEL NVKVLEALEL
   361  YNKLVNEAPV YSVYSKLHPP AHYPPASSGV PMQTYPVQSH GGNYMGQSIH QVTVAQSYSL
   421  GPDQIGPLRS LPPNVNSSVT AQPAQTSYLS TGQDTVSNPT YMNQNSNLQS ATGTTAYTQQ
   481  MGMSVDMSSY QNTTSNLPQL AGFPVTVPAH PVAQQHTNYH QQPLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STAM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
14 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 14 nTPM
  • thyroid gland: 13 nTPM
  • fallopian tube: 12 nTPM
  • prostate: 12 nTPM
  • parathyroid gland: 12 nTPM
  • testis: 12 nTPM

Single-cell type

  • late primary spermatocytes: 178 nCPM
  • distal convoluted tubule cells: 151 nCPM
  • respiratory ciliated cells: 141 nCPM
  • early spermatids: 128 nCPM
  • neutrophils: 126 nCPM
  • fallopian tube ciliated cells: 113 nCPM

Immune cell

  • basophil: 17 nTPM
  • neutrophil: 8.6 nTPM
  • non-classical monocyte: 7.2 nTPM
  • eosinophil: 4.7 nTPM
  • intermediate monocyte: 4.6 nTPM
  • classical monocyte: 3.4 nTPM

Brain region

  • white matter: 19 nTPM
  • basal ganglia: 16 nTPM
  • choroid plexus: 16 nTPM
  • spinal cord: 16 nTPM
  • midbrain: 16 nTPM
  • medulla oblongata: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.73
gnomAD pLI
0
gnomAD missense Z
0.35
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STAM2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STAM2 as an antibody target. Whether an autoantibody or antibody against STAM2 could matter depends on whether native STAM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STAM2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STAM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STAM2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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