Seroatlas · Human Serome Atlas

GCC1

GRIP and coiled-coil domain-containing protein 1

Also known as: FLJ22035, GCC1_HUMAN, GCC1P, GCC88, MGC20706

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96CN9
Gene: GCC1
Ensembl: ENSG00000179562
Chromosome: 7
Canonical length: 775 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a peripheral membrane protein. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. It may play a role in the organization of trans-Golgi network subcompartment involved with membrane transport. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

775 residues, UniProt reviewed canonical sequence.

>Q96CN9|GCC1
     1  MEKFGMNFGG GPSKKDLLET IETQKKQLLQ YQARLKDVVR AYKSLLKEKE ALEASIKVLS
    61  VSHEADVGLA GVQLPGLTFP DSVDDRCSTH SEDSTGTATS LDTAASLTST KGEFGVEDDR
   121  PARGPPPPKS EEASWSESGV SSSSGDGPFA GGEVDKRLHQ LKTQLATLTS SLATVTQEKS
   181  RMEASYLADK KKMKQDLEDA SNKAEEERAR LEGELKGLQE QIAETKARLI TQQHDRAQEQ
   241  SDHALMLREL QKLLQEERTQ RQDLELRLEE TREALAGRAY AAEQMEGFEL QTKQLTREVE
   301  ELKSELQAIR DEKNQPDPRL QELQEEAARL KSHFQAQLQQ EMRKTALAED QLRQQSQVEE
   361  QRVAALENQI SEVSELLGTY EKAKQKDQLA IQKLKERILQ LDLENKTLAL AASSRSPLDS
   421  HGEESSLDVN VLKDKMEKLK RLLQVAARKS QVTLDVEKLC DLEIMPSSEA ADGEKATALY
   481  YQQELKQLKE EFERYKMRAQ VVLKSKNTKD GNLGKELEAA QEQLAELKEK YISLRLSCEE
   541  LEHQHQQEAD DWKQELARLQ QLHRQELERC QLDFRDRTLK LEEELHKQRD RALAVLTEKD
   601  LELEQLRSVA LASGLPGRRS PVGGGGPGDP ADTSSSDSLT QALQLAAANE PTFFLYAEQL
   661  ARKEVEITSL RKQKHRLEVE VHQLQDRLLE EGERHREEVA ALQSHIEKNI RDQSREGANL
   721  EYLKNIIYRF LTLPDSLGRQ QTLTAILTIL HFSPEEKQVI MRLPTSASWW PSGKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GCC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 13 nTPM
testis: 11 nTPM
liver: 9.9 nTPM
tonsil: 9.3 nTPM
parathyroid gland: 8.8 nTPM
breast: 8.6 nTPM

Single-cell type

late spermatids: 178 nCPM
early spermatids: 164 nCPM
epicardial cells: 114 nCPM
cardiomyocytes: 106 nCPM
adipocytes: 33 nCPM
neutrophils: 20 nCPM

Immune cell

eosinophil: 13 nTPM
neutrophil: 13 nTPM
MAIT T-cell: 9.1 nTPM
NK-cell: 8.8 nTPM
non-classical monocyte: 8.3 nTPM
total PBMC: 8.1 nTPM

Brain region

white matter: 12 nTPM
cerebellum: 11 nTPM
medulla oblongata: 11 nTPM
midbrain: 11 nTPM
basal ganglia: 11 nTPM
spinal cord: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.8
gnomAD pLI: 0
gnomAD missense Z: 0.63
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

small GTPase binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GCC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GCC1 as an antibody target. Whether an autoantibody or antibody against GCC1 could matter depends on whether native GCC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GCC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GCC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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