Seroatlas · Human Serome Atlas

ARMC7

Armadillo repeat-containing protein 7

Also known as: ARMC7_HUMAN, FLJ22160

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H6L4
Gene: ARMC7
Ensembl: ENSG00000125449
Chromosome: 17
Canonical length: 198 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to be involved in RNA splicing and mRNA processing. Predicted to be part of spliceosomal complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

198 residues, UniProt reviewed canonical sequence.

>Q9H6L4|ARMC7
     1  MAQKPKVDPH VGRLGYLQAL VTEFQETQSQ DAKEQVLANL ANFAYDPSNY EYLRQLQVLD
    61  LFLDSLSEEN ETLVEFAIGG LCNLCPDRAN KEHILHAGGV PLIINCLSSP NEETVLSAIT
   121  TLMHLSPPGR SFLPELTATP VVQCMLRFSL SASARLRNLA QIFLEDFCSP RQVAEARSRQ
   181  AHSALGIPLP RSVAPRQR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARMC7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

kidney: 31 nTPM
cerebellum: 16 nTPM
spleen: 13 nTPM
liver: 13 nTPM
lung: 12 nTPM
colon: 12 nTPM

Single-cell type

paneth cells: 66 nCPM
renal collecting duct intercalated cells: 61 nCPM
renal collecting duct principal cells: 57 nCPM
oocytes: 51 nCPM
platelets: 44 nCPM
colonocytes: 34 nCPM

Immune cell

basophil: 32 nTPM
eosinophil: 29 nTPM
T-reg: 21 nTPM
neutrophil: 19 nTPM
gdT-cell: 18 nTPM
MAIT T-cell: 16 nTPM

Brain region

cerebellum: 21 nTPM
white matter: 11 nTPM
hypothalamus: 11 nTPM
choroid plexus: 11 nTPM
cerebral cortex: 11 nTPM
pons: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0.04
gnomAD missense Z: -0.09
DepMap mean gene effect: -1.34
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

spliceosomal complex

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARMC7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARMC7 as an antibody target. Whether an autoantibody or antibody against ARMC7 could matter depends on whether native ARMC7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARMC7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARMC7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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