Seroatlas · Human Serome Atlas

BRK1

Protein BRICK1

Also known as: BRK1_HUMAN, C3orf10, HSPC300, MDS027

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WUW1
Gene: BRK1
Ensembl: ENSG00000254999
Chromosome: 3
Canonical length: 75 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Cell Junctions
Quaternary structure: Homotrimer

OverviewNCBI Gene

Enables identical protein binding activity. Contributes to small GTPase binding activity. Involved in Rac protein signal transduction and positive regulation of cellular component organization. Located in extracellular exosome. Part of SCAR complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

75 residues, UniProt reviewed canonical sequence.

>Q8WUW1|BRK1
     1  MAGQEDPVQR EIHQDWANRE YIEIITSSIK KIADFLNSFD MSCRSRLATL NEKLTALERR
    61  IEYIEARVTK GETLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BRK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 236 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 236 nTPM
kidney: 198 nTPM
colon: 192 nTPM
urinary bladder: 188 nTPM
skeletal muscle: 186 nTPM
esophagus: 185 nTPM

Single-cell type

late spermatids: 3,909 nCPM
esophageal apical cells: 1,840 nCPM
early spermatids: 1,131 nCPM
esophageal suprabasal cells: 871 nCPM
megakaryocytes: 569 nCPM
hofbauer cells: 567 nCPM

Immune cell

total PBMC: 470 nTPM
plasmacytoid DC: 406 nTPM
myeloid DC: 381 nTPM
eosinophil: 358 nTPM
non-classical monocyte: 347 nTPM
neutrophil: 339 nTPM

Brain region

cerebral cortex: 95 nTPM
hypothalamus: 94 nTPM
thalamus: 90 nTPM
spinal cord: 85 nTPM
white matter: 84 nTPM
basal ganglia: 83 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0.69
gnomAD missense Z: 1.21
DepMap mean gene effect: -0.25
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Protein BRICK1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BRK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BRK1 as an antibody target. Whether an autoantibody or antibody against BRK1 could matter depends on whether native BRK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BRK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BRK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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