Seroatlas · Human Serome Atlas

MRFAP1L1

MORF4 family-associated protein 1-like 1

Also known as: MGC9651, MR1L1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96HT8
Gene: MRFAP1L1
Ensembl: ENSG00000178988
Chromosome: 4
Canonical length: 127 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables identical protein binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

127 residues, UniProt reviewed canonical sequence.

>Q96HT8|MRFAP1L1
     1  MRPLDIDEVE APEEVEVLEP EEDFEQFLLP VINEMREDIA SLIREHGRAY LRTRSKLWEM
    61  DNMLIQIKTQ VEASEESALN HVQHPSGEAD ERVSELCEKA EEKAKEIAKM AEMLVELVWR
   121  IERSESS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRFAP1L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 71 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 71 nTPM
hypothalamus: 68 nTPM
amygdala: 68 nTPM
spinal cord: 67 nTPM
basal ganglia: 67 nTPM
midbrain: 65 nTPM

Single-cell type

esophageal apical cells: 90 nCPM
esophageal suprabasal cells: 50 nCPM
migrating cytotrophoblasts: 48 nCPM
cytotrophoblasts: 47 nCPM
parietal cells: 46 nCPM
early primary spermatocytes: 42 nCPM

Immune cell

basophil: 289 nTPM
eosinophil: 171 nTPM
memory CD8 T-cell: 150 nTPM
gdT-cell: 144 nTPM
T-reg: 144 nTPM
MAIT T-cell: 142 nTPM

Brain region

spinal cord: 51 nTPM
hypothalamus: 48 nTPM
basal ganglia: 47 nTPM
white matter: 46 nTPM
thalamus: 46 nTPM
cerebellum: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.73
gnomAD pLI: 0
gnomAD missense Z: -0.41
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

identical protein binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

InteractionsUniProt · HPA

Protein binding partners of MRFAP1L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRFAP1L1 as an antibody target. Whether an autoantibody or antibody against MRFAP1L1 could matter depends on whether native MRFAP1L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRFAP1L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRFAP1L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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