Zinc finger and BTB domain-containing
IPR050457
Definition
The Zinc finger and BTB domain-containing protein family is involved in transcriptional regulation, with members acting as transcriptional repressors or activators. They bind to specific DNA sequences, regulate chromatin organization, and recruit transcription factors to gene regulatory regions. Some family members are implicated in lineage commitment of T-cell precursors, tumor suppression, metabolic regulation, and response to oxidative stress. They interact with various proteins, including HDACs, NuRD complex, and androgen receptor, influencing cell proliferation, differentiation, and immune responses. The family also plays roles in myogenesis, adipogenesis, chondrogenesis, and DNA repair.
29 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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