Seroatlas · Human Serome Atlas

ZNF710

Zinc finger protein 710

Also known as: DKFZp547K1113, FLJ00306, FLJ37393, ZN710_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N1W2
Gene: ZNF710
Ensembl: ENSG00000140548
Chromosome: 15
Canonical length: 664 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

664 residues, UniProt reviewed canonical sequence.

>Q8N1W2|ZNF710
     1  MEGFMDSGTQ TDAVVVLSLA QAAVLGLVSE NELFGATISA EAFYPDLGPE LSGAAMGEPE
    61  PPGPDVYQLA CNGRALEEPA EEEVLEVEAA CEKHTRRKTR PPVRLVPKVK FEKVEEEEQE
   121  VYEVSVPGDD KDAGPAEAPA EAASGGCDAL VQSSAVKMID LSAFSRKPRT LRHLPRTPRP
   181  ELNVAPYDPH FPAPARDGFP EPSMALPGPE ALPTECGFEP PHLAPLSDPE APSMESPEPV
   241  KPEQGFVWQE ASEFEADTAG STVERHKKAQ LDRLDINVQI DDSYLVEAGD RQKRWQCRMC
   301  EKSYTSKYNL VTHILGHNGI KPHSCPHCSK LFKQPSHLQT HLLTHQGTRP HKCQVCHKAF
   361  TQTSHLKRHM LLHSEVKPYS CHFCGRGFAY PSELKAHEVK HESGRCHVCV ECGLDFSTLT
   421  QLKRHLASHQ GPTLYQCLEC DKSFHYRSQL QNHMLKHQNV RPFVCTECGM EFSQIHHLKQ
   481  HSLTHKGVKE FKCEVCGREF TLQANMKRHM LIHTSVRPYQ CHICFKTFVQ KQTLKTHMIV
   541  HSPVKPFKCK VCGKSFNRMY NLLGHMHLHA GSKPFKCPYC SSKFNLKGNL SRHMKVKHGV
   601  MDIGLDSQDP MMELTGTDPS ELDGQQEMED FEENAYSYAS VDSSAEASVL TEQAMKEMAY
   661  YNVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF710 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

pancreas: 42 nTPM
skeletal muscle: 31 nTPM
esophagus: 16 nTPM
appendix: 14 nTPM
spleen: 13 nTPM
skin: 12 nTPM

Single-cell type

microglia: 540 nCPM
neutrophils: 251 nCPM
cdc: 223 nCPM
macrophages: 203 nCPM
tuft cells: 196 nCPM
monocytes: 191 nCPM

Immune cell

non-classical monocyte: 5.7 nTPM
intermediate monocyte: 3.5 nTPM
neutrophil: 1.9 nTPM
classical monocyte: 1.6 nTPM
plasmacytoid DC: 1.4 nTPM
eosinophil: 1.2 nTPM

Brain region

midbrain: 53 nTPM
pons: 50 nTPM
thalamus: 50 nTPM
medulla oblongata: 50 nTPM
basal ganglia: 50 nTPM
amygdala: 48 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZNF710.

Disease | ImmuneIEDB

Conditions an epitope on ZNF710 was assayed in.

human immunodeficiency virus infectious disease T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.28
gnomAD pLI: 0.99
gnomAD missense Z: 2.42
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF710 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DYNLL1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF710 as an antibody target. Whether an autoantibody or antibody against ZNF710 could matter depends on whether native ZNF710 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF710 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF710 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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