Leucine-rich repeat domain-containing protein
IPR050216
Definition
This family of proteins includes a diverse range of functions, primarily associated with cellular signaling and regulation. Members are involved in innate immunity, acting as regulators of Toll-like receptor signaling pathways, and contributing to inflammatory responses. Some proteins within the family function as GTP-binding proteins, while others are involved in the MAPK pathway activation, acting as Ras effectors. The family also includes proteins that participate in the regulation of cell volume through the volume-regulated anion channel (VRAC), mediating ion transport in response to osmotic changes. Additionally, there are proteins that play roles in apoptosis, cell survival, and ubiquitination processes. The proteins are characterized by the presence of leucine-rich repeat (LRR) domains, which are typically involved in protein-protein interactions and may contribute to the diverse functional roles of the family.
30 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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