Seroatlas · Human Serome Atlas

LRRC10

Leucine-rich repeat-containing protein 10

Also known as: HRLRRP, LRC10_HUMAN, LRRC10A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5BKY1
Gene: LRRC10
Ensembl: ENSG00000198812
Chromosome: 12
Canonical length: 277 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable actin binding activity. Predicted to be involved in cardiac muscle cell development. Predicted to be located in mitochondrion; myofibril; and nucleus. Predicted to be active in cytoskeleton and sarcomere. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

277 residues, UniProt reviewed canonical sequence.

>Q5BKY1|LRRC10
     1  MGNTIRALVA FIPADRCQNY VVRDLREMPL DKMVDLSGSQ LRRFPLHVCS FRELVKLYLS
    61  DNHLNSLPPE LGQLQNLQIL ALDFNNFKAL PQVVCTLKQL CILYLGNNKL CDLPSELSLL
   121  QNLRTLWIEA NCLTQLPDVV CELSLLKTLH AGSNALRLLP GQLRRLQELR TIWLSGNRLT
   181  DFPTVLLHMP FLEVIDVDWN SIRYFPSLAH LSSLKLVIYD HNPCRNAPKV AKGVRRVGRW
   241  AEETPEPDPR KARRYALVRE ESQELQAPVP LLPPTNS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 37 nTPM
lymph node: 0.6 nTPM
appendix: 0.3 nTPM
bone marrow: 0.2 nTPM
lung: 0.2 nTPM
skin: 0.2 nTPM

Single-cell type

cardiomyocytes: 4.1 nCPM
adipocytes: 1.7 nCPM
late primary spermatocytes: 0.1 nCPM
vascular endothelial cells: 0.1 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM

Immune cell

naive B-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebellum: 2.6 nTPM
basal ganglia: 2.3 nTPM
cerebral cortex: 2.3 nTPM
hippocampal formation: 2.2 nTPM
amygdala: 2 nTPM
white matter: 1.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.88
gnomAD pLI: 0.43
gnomAD missense Z: 0.39
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cardiac muscle cell development

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC10 as an antibody target. Whether an autoantibody or antibody against LRRC10 could matter depends on whether native LRRC10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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