LRRC8E

Protein identityUniProt · HPA

UniProt accession

Q6NSJ5

Gene

LRRC8E

Ensembl

ENSG00000171017

Chromosome

19

Canonical length

796 aa

Protein class

Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of a small, conserved family of proteins with similar structure, including a string of extracellular leucine-rich repeats. A related protein was shown to be involved in B-cell development. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]

Canonical amino-acid sequenceUniProt

796 residues, UniProt reviewed canonical sequence.

>Q6NSJ5|LRRC8E
     1  MIPVAEFKQF TEQQPAFKVL KPWWDVLAEY LTVAMLMIGV FGCTLQVTQD KIICLPNHEL
    61  QENLSEAPCQ QLLPRGIPEQ IGALQEVKGL KNNLDLQQYS FINQLCYETA LHWYAKYFPY
   121  LVVIHTLIFM VCTSFWFKFP GTSSKIEHFI SILGKCFDSP WTTRALSEVS GENQKGPAAT
   181  ERAAATIVAM AGTGPGKAGE GEKEKVLAEP EKVVTEPPVV TLLDKKEGEQ AKALFEKVKK
   241  FRMHVEEGDI LYTMYIRQTV LKVCKFLAIL VYNLVYVEKI SFLVACRVET SEVTGYASFC
   301  CNHTKAHLFS KLAFCYISFV CIYGLTCIYT LYWLFHRPLK EYSFRSVREE TGMGDIPDVK
   361  NDFAFMLHLI DQYDSLYSKR FAVFLSEVSE SRLKQLNLNH EWTPEKLRQK LQRNAAGRLE
   421  LALCMLPGLP DTVFELSEVE SLRLEAICDI TFPPGLSQLV HLQELSLLHS PARLPFSLQV
   481  FLRDHLKVMR VKCEELREVP LWVFGLRGLE ELHLEGLFPQ ELARAATLES LRELKQLKVL
   541  SLRSNAGKVP ASVTDVAGHL QRLSLHNDGA RLVALNSLKK LAALRELELV ACGLERIPHA
   601  VFSLGALQEL DLKDNHLRSI EEILSFQHCR KLVTLRLWHN QIAYVPEHVR KLRSLEQLYL
   661  SYNKLETLPS QLGLCSGLRL LDVSHNGLHS LPPEVGLLQN LQHLALSYNA LEALPEELFF
   721  CRKLRTLLLG DNQLSQLSPH VGALRALSRL ELKGNRLEAL PEELGNCGGL KKAGLLVEDT
   781  LYQGLPAEVR DKMEEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC8E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

4

Mean surface accessibility (rSASA)

0.29

Highest tissue expression

10 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.88

gnomAD pLI

0

gnomAD missense Z

0.37

DepMap mean gene effect

-0.13

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• aspartate transmembrane transport
• cell volume homeostasis
• cellular response to osmotic stress
• cyclic-GMP-AMP transmembrane import across plasma membrane
• monoatomic anion transmembrane transport

Molecular functions

• volume-sensitive anion channel activity

Cellular components

• cytoplasm
• endoplasmic reticulum membrane
• lysosomal membrane
• monoatomic ion channel complex
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Leucine-rich repeat
• Leucine-rich repeat, typical subtype
• LRRC8, pannexin-like TM region
• Leucine-rich repeat domain superfamily
• Leucine-rich repeat domain-containing protein
• Leucine Rich Repeat
• Pannexin-like TM region of LRRC8
• Leucine rich repeat

KeywordsUniProt

• Cell membrane
• Disulfide bond
• Endoplasmic reticulum
• Glycoprotein
• Ion channel
• Ion transport
• Leucine-rich repeat
• Lysosome
• Membrane
• Repeat
• Transmembrane
• Transmembrane helix
• Transport

InteractionsUniProt · HPA

Protein binding partners of LRRC8E in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• LNX2
• TRIM2