Seroatlas · Human Serome Atlas

LRRC18

Leucine-rich repeat-containing protein 18

Also known as: LRC18_HUMAN, MGC34773, UNQ933, UNQ9338, VKGE9338

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N456
Gene: LRRC18
Ensembl: ENSG00000165383
Chromosome: 10
Canonical length: 261 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to be involved in intracellular signal transduction. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

261 residues, UniProt reviewed canonical sequence.

>Q8N456|LRRC18
     1  MVKGEKGPKG KKITLKVARN CIKITFDGKK RLDLSKMGIT TFPKCILRLS DMDELDLSRN
    61  LIRKIPDSIS KFQNLRWLDL HSNYIDKLPE SIGQMTSLLY LNVSNNRLTS NGLPVELKQL
   121  KNIRAVNLGL NHLDSVPTTL GALKELHEVG LHDNLLNNIP VSISKLPKLK KLNIKRNPFP
   181  KPGESEIFID SIRRLENLYV VEEKDLCAAC LRKCQNARDN LNRIKNMATT TPRKTIFPNL
   241  ISPNSMAKDS WEDWRIRLTS S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 23 nTPM
testis: 13 nTPM
fallopian tube: 6.2 nTPM
lung: 1.3 nTPM
skin: 0.7 nTPM
bone marrow: 0.5 nTPM

Single-cell type

cdc: 12 nCPM
late spermatids: 10 nCPM
early spermatids: 8.4 nCPM
late primary spermatocytes: 6 nCPM
respiratory ciliated cells: 4.3 nCPM
fallopian tube ciliated cells: 1.9 nCPM

Immune cell

memory B-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

choroid plexus: 24 nTPM
medulla oblongata: 3 nTPM
midbrain: 2.6 nTPM
pons: 2.5 nTPM
white matter: 2.5 nTPM
hippocampal formation: 2.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.9
gnomAD pLI: 0
gnomAD missense Z: -0.73
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

intracellular signal transduction

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC18 as an antibody target. Whether an autoantibody or antibody against LRRC18 could matter depends on whether native LRRC18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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