Seroatlas · Human Serome Atlas

LRRC8D

Volume-regulated anion channel subunit LRRC8D

Also known as: FLJ10470, LRC8D_HUMAN, LRRC5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7L1W4
Gene
LRRC8D
Ensembl
ENSG00000171492
Chromosome
1
Canonical length
858 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Enables volume-sensitive anion channel activity. Involved in several processes, including monoatomic anion transmembrane transport; organic acid transmembrane transport; and protein hexamerization. Located in cytoplasm and plasma membrane. Part of monoatomic ion channel complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

858 residues, UniProt reviewed canonical sequence.

>Q7L1W4|LRRC8D
     1  MFTLAEVASL NDIQPTYRIL KPWWDVFMDY LAVVMLMVAI FAGTMQLTKD QVVCLPVLPS
    61  PVNSKAHTPP GNAEVTTNIP KMEAATNQDQ DGRTTNDISF GTSAVTPDIP LRATYPRTDF
   121  ALPNQEAKKE KKDPTGRKTN LDFQQYVFIN QMCYHLALPW YSKYFPYLAL IHTIILMVSS
   181  NFWFKYPKTC SKVEHFVSIL GKCFESPWTT KALSETACED SEENKQRITG AQTLPKHVST
   241  SSDEGSPSAS TPMINKTGFK FSAEKPVIEV PSMTILDKKD GEQAKALFEK VRKFRAHVED
   301  SDLIYKLYVV QTVIKTAKFI FILCYTANFV NAISFEHVCK PKVEHLIGYE VFECTHNMAY
   361  MLKKLLISYI SIICVYGFIC LYTLFWLFRI PLKEYSFEKV REESSFSDIP DVKNDFAFLL
   421  HMVDQYDQLY SKRFGVFLSE VSENKLREIS LNHEWTFEKL RQHISRNAQD KQELHLFMLS
   481  GVPDAVFDLT DLDVLKLELI PEAKIPAKIS QMTNLQELHL CHCPAKVEQT AFSFLRDHLR
   541  CLHVKFTDVA EIPAWVYLLK NLRELYLIGN LNSENNKMIG LESLRELRHL KILHVKSNLT
   601  KVPSNITDVA PHLTKLVIHN DGTKLLVLNS LKKMMNVAEL ELQNCELERI PHAIFSLSNL
   661  QELDLKSNNI RTIEEIISFQ HLKRLTCLKL WHNKIVTIPP SITHVKNLES LYFSNNKLES
   721  LPVAVFSLQK LRCLDVSYNN ISMIPIEIGL LQNLQHLHIT GNKVDILPKQ LFKCIKLRTL
   781  NLGQNCITSL PEKVGQLSQL TQLELKGNCL DRLPAQLGQC RMLKKSGLVV EDHLFDTLPL
   841  EVKEALNQDI NIPFANGI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC8D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
42 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 42 nTPM
  • thymus: 26 nTPM
  • adrenal gland: 25 nTPM
  • kidney: 24 nTPM
  • hippocampal formation: 24 nTPM
  • lymph node: 23 nTPM

Single-cell type

  • pituicytes/fscs: 58 nCPM
  • megakaryocytes: 56 nCPM
  • platelets: 45 nCPM
  • retinal pigment epithelial cells: 43 nCPM
  • oligodendrocytes: 34 nCPM
  • hepatocytes: 33 nCPM

Immune cell

  • T-reg: 17 nTPM
  • memory CD4 T-cell: 16 nTPM
  • naive CD4 T-cell: 15 nTPM
  • NK-cell: 13 nTPM
  • MAIT T-cell: 12 nTPM
  • naive CD8 T-cell: 12 nTPM

Brain region

  • white matter: 170 nTPM
  • basal ganglia: 101 nTPM
  • medulla oblongata: 100 nTPM
  • pons: 95 nTPM
  • midbrain: 93 nTPM
  • spinal cord: 92 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.31
gnomAD pLI
0.98
gnomAD missense Z
3.2
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC8D as an antibody target. Whether an autoantibody or antibody against LRRC8D could matter depends on whether native LRRC8D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC8D is annotated at the cell surface, where native LRRC8D is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LRRC8D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LRRC8D. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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