Seroatlas · Human Serome Atlas

LRRD1

Leucine-rich repeat and death domain-containing protein 1

Also known as: IMAGE:4798971, LRRD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A4D1F6
Gene: LRRD1
Ensembl: ENSG00000240720
Chromosome: 7
Canonical length: 860 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in signal transduction. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

860 residues, UniProt reviewed canonical sequence.

>A4D1F6|LRRD1
     1  MSEKEGMSEV LEDTISQFRK ESRSQSMKEP GFIKETSNLI NEASDYLEGK SSNQIYETHP
    61  RQNTLESTSS SGRKSKRNEE QKKNLQFSET STRTGTSQSL SSLTGRTAEY QALVNFLSHE
   121  TVGEVSPQVS EENQKQLGLG ADNFTVNLEA KGLQEFPKDI LKIKYVKYLY LDKNQIKTFQ
   181  GADSGDLLGL EILSLQENGL SSLPSEIQLL HNLRILNVSH NHISHIPKEI SQLGNIRQLF
   241  FYNNYIENFP SDLECLGNLE ILSLGKNKLR HIPDTLPSLK TLRVLNLEYN QLTTFPKALC
   301  FLPKLISLDL TGNLISSLPK EIRELKNLET LLMDHNKLTF LAVEIFQLLK IKELQLADNK
   361  LEVISHKIEN FRELRILILD KNLLKNIPEK ISCCAMLECL SLSDNKLTEL PKYIHKLNNL
   421  RKLHVNRNNM VKITDCISHL NNICSLEFSG NIITDVPIEI KNCQKIIKIE LSYNKIMYFP
   481  LGLCALDSLY YLSVNGNYIS EIPVDISFSK QLLHLELSEN KLLIFSEHFC SLINLKYLDL
   541  GKNQIKKIPA SISNMISLHV LILCCNKFET FPRELCTLEN LQVLDLSENQ LQKISSDICN
   601  LKGIQKLNFS SNQFIHFPIE LCQLQSLEQL NISQIKGRKL TRLPGELSNM TQLKELDISN
   661  NAIREIPRNI GELRNLVSLH AYNNQISYLP PSLLSLNDLQ QLNLSGNNLT ALPSAIYNIF
   721  SLKEINFDDN PLLRPPVEIC KGKQLYTIAR YLQRADERDE KILEKIFKIV ANNITETNFE
   781  FLCQKLNLAN SETDMPTKST VSLSERAHQA LVIWKTQSNK LSLTAAALRD QLIRALTMIG
   841  AYEIMDKITA LNLFTRAIKF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

testis: 14 nTPM
retina: 0.4 nTPM
bone marrow: 0.3 nTPM
epididymis: 0.3 nTPM
skin: 0.3 nTPM
cerebellum: 0.2 nTPM

Single-cell type

late spermatids: 12 nCPM
early spermatids: 4 nCPM
renal collecting duct intercalated cells: 2.2 nCPM
distal convoluted tubule cells: 1.6 nCPM
loop of henle epithelial cells: 1.6 nCPM
proximal tubule cells: 1.6 nCPM

Immune cell

basophil: 0.7 nTPM
neutrophil: 0.5 nTPM
classical monocyte: 0.1 nTPM
gdT-cell: 0.1 nTPM
memory B-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM

Brain region

cerebellum: 6.3 nTPM
white matter: 5.3 nTPM
hypothalamus: 4.8 nTPM
cerebral cortex: 4.7 nTPM
pons: 4.6 nTPM
medulla oblongata: 4.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.88
gnomAD pLI: 0
gnomAD missense Z: 1.53
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRD1 as an antibody target. Whether an autoantibody or antibody against LRRD1 could matter depends on whether native LRRD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...