Seroatlas · Human Serome Atlas

LRCH4

Leucine-rich repeat and calponin homology domain-containing protein 4

Also known as: LRCH4_HUMAN, LRN, LRRN1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75427
Gene: LRCH4
Ensembl: ENSG00000077454
Chromosome: 7
Canonical length: 683 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Focal adhesion sites,Cytosol

OverviewNCBI Gene

This gene encodes a protein that contains leucine-rich repeats (LRR) at its amino terminus and that is known to be involved in ligand binding. The carboxyl terminus may act as a membrane anchor. Identified structural elements suggest that the encoded protein resembles a receptor. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

683 residues, UniProt reviewed canonical sequence.

>O75427|LRCH4
     1  MAAAVAAPLA AGGEEAAATT SVPGSPGLPG RRSAERALEE AVATGTLNLS NRRLKHFPRG
    61  AARSYDLSDI TQADLSRNRF PEVPEAACQL VSLEGLSLYH NCLRCLNPAL GNLTALTYLN
   121  LSRNQLSLLP PYICQLPLRV LIVSNNKLGA LPPDIGTLGS LRQLDVSSNE LQSLPSELCG
   181  LSSLRDLNVR RNQLSTLPEE LGDLPLVRLD FSCNRVSRIP VSFCRLRHLQ VILLDSNPLQ
   241  SPPAQVCLKG KLHIFKYLST EAGQRGSALG DLAPSRPPSF SPCPAEDLFP GHRYDGGLDS
   301  GFHSVDSGSK RWSGNESTDE FSELSFRISE LAREPRGPRE RKEDGSADGD PVQIDFIDSH
   361  VPGEDEERGT VEEQRPPELS PGAGDRERAP SSRREEPAGE ERRRPDTLQL WQERERRQQQ
   421  QSGAWGAPRK DSLLKPGLRA VVGGAAAVST QAMHNGSPKS SASQAGAAAG QGAPAPAPAS
   481  QEPLPIAGPA TAPAPRPLGS IQRPNSFLFR SSSQSGSGPS SPDSVLRPRR YPQVPDEKDL
   541  MTQLRQVLES RLQRPLPEDL AEALASGVIL CQLANQLRPR SVPFIHVPSP AVPKLSALKA
   601  RKNVESFLEA CRKMGVPEAD LCSPSDLLQG TARGLRTALE AVKRVGGKAL PPLWPPSGLG
   661  GFVVFYVVLM LLLYVTYTRL LGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRCH4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 112 nTPM

Expression across tissuesHPA

Tissue

spleen: 112 nTPM
testis: 79 nTPM
small intestine: 60 nTPM
bone marrow: 57 nTPM
ovary: 53 nTPM
lung: 48 nTPM

Single-cell type

astrocytes: 24 nCPM
tuft cells: 23 nCPM
podocytes: 20 nCPM
renal collecting duct intercalated cells: 18 nCPM
choroid plexus epithelial cells: 14 nCPM
microglia: 14 nCPM

Immune cell

neutrophil: 16 nTPM
eosinophil: 10 nTPM
basophil: 10 nTPM
classical monocyte: 5.6 nTPM
naive CD4 T-cell: 5.2 nTPM
naive B-cell: 5.1 nTPM

Brain region

white matter: 39 nTPM
medulla oblongata: 36 nTPM
cerebral cortex: 33 nTPM
thalamus: 33 nTPM
pons: 32 nTPM
basal ganglia: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0
gnomAD missense Z: -0.12
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRCH4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRCH4 as an antibody target. Whether an autoantibody or antibody against LRCH4 could matter depends on whether native LRCH4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRCH4 is annotated at the cell surface, where native LRCH4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LRCH4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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