Seroatlas · Human Serome Atlas

LRRC8C

Volume-regulated anion channel subunit LRRC8C

Also known as: AD158, LRC8C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TDW0
Gene: LRRC8C
Ensembl: ENSG00000171488
Chromosome: 1
Canonical length: 803 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus
Quaternary structure: Homoheptamer

OverviewNCBI Gene

Enables volume-sensitive anion channel activity. Involved in cyclic-GMP-AMP transmembrane import across plasma membrane and monoatomic anion transmembrane transport. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

803 residues, UniProt reviewed canonical sequence.

>Q8TDW0|LRRC8C
     1  MIPVTEFRQF SEQQPAFRVL KPWWDVFTDY LSVAMLMIGV FGCTLQVMQD KIICLPKRVQ
    61  PAQNHSSLSN VSQAVASTTP LPPPKPSPAN PITVEMKGLK TDLDLQQYSF INQMCYERAL
   121  HWYAKYFPYL VLIHTLVFML CSNFWFKFPG SSSKIEHFIS ILGKCFDSPW TTRALSEVSG
   181  EDSEEKDNRK NNMNRSNTIQ SGPEDSLVNS QSLKSIPEKF VVDKSTAGAL DKKEGEQAKA
   241  LFEKVKKFRL HVEEGDILYA MYVRQTVLKV IKFLIIIAYN SALVSKVQFT VDCNVDIQDM
   301  TGYKNFSCNH TMAHLFSKLS FCYLCFVSIY GLTCLYTLYW LFYRSLREYS FEYVRQETGI
   361  DDIPDVKNDF AFMLHMIDQY DPLYSKRFAV FLSEVSENKL KQLNLNNEWT PDKLRQKLQT
   421  NAHNRLELPL IMLSGLPDTV FEITELQSLK LEIIKNVMIP ATIAQLDNLQ ELSLHQCSVK
   481  IHSAALSFLK ENLKVLSVKF DDMRELPPWM YGLRNLEELY LVGSLSHDIS RNVTLESLRD
   541  LKSLKILSIK SNVSKIPQAV VDVSSHLQKM CIHNDGTKLV MLNNLKKMTN LTELELVHCD
   601  LERIPHAVFS LLSLQELDLK ENNLKSIEEI VSFQHLRKLT VLKLWHNSIT YIPEHIKKLT
   661  SLERLSFSHN KIEVLPSHLF LCNKIRYLDL SYNDIRFIPP EIGVLQSLQY FSITCNKVES
   721  LPDELYFCKK LKTLKIGKNS LSVLSPKIGN LLFLSYLDVK GNHFEILPPE LGDCRALKRA
   781  GLVVEDALFE TLPSDVREQM KTE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC8C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

smooth muscle: 15 nTPM
adipose tissue: 13 nTPM
lymph node: 12 nTPM
spleen: 8.7 nTPM
appendix: 8.5 nTPM
choroid plexus: 7.8 nTPM

Single-cell type

late spermatids: 9.5 nCPM
early spermatids: 4.9 nCPM
innate lymphoid cells: 1 nCPM
granulosa cells: 0.8 nCPM
late primary spermatocytes: 0.6 nCPM
microglia: 0.6 nCPM

Immune cell

T-reg: 11 nTPM
myeloid DC: 9 nTPM
non-classical monocyte: 6.6 nTPM
memory CD4 T-cell: 6.1 nTPM
classical monocyte: 6 nTPM
intermediate monocyte: 5.2 nTPM

Brain region

choroid plexus: 26 nTPM
white matter: 14 nTPM
cerebral cortex: 13 nTPM
pons: 12 nTPM
midbrain: 12 nTPM
spinal cord: 12 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LRRC8C.

Disease | AllUniProt

Conditions LRRC8C is implicated in, by any mechanism.

Telangiectasia, impaired intellectual development, microcephaly, metaphyseal dysplasia, eye abnormalities, and short stature (TIMES) MIM:621056

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 72 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Telangiectasia, impaired intellectual development, microcephaly, metaphyseal dysplasia, eye abnormalities, and short stature

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.64
gnomAD pLI: 0
gnomAD missense Z: 2.58
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

volume-sensitive anion channel activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC8C as an antibody target. Whether an autoantibody or antibody against LRRC8C could matter depends on whether native LRRC8C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC8C is annotated at the cell surface, where native LRRC8C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LRRC8C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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