Seroatlas · Human Serome Atlas

LRCH1

Leucine-rich repeat and calponin homology domain-containing protein 1

Also known as: CHDC1, KIAA1016, LRCH1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2L9
Gene: LRCH1
Ensembl: ENSG00000136141
Chromosome: 13
Canonical length: 728 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoli,Actin filaments,Cytosol

OverviewNCBI Gene

This gene encodes a protein with a leucine-rich repeat and a calponin homology domain. Polymorphism in this gene may be associated with susceptibililty to knee osteoarthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

728 residues, UniProt reviewed canonical sequence.

>Q9Y2L9|LRCH1
     1  MATPGSEPQP FVPALSVATL HPLHHPHHHH HHHQHHGGTG APGGAGGGGG GSGGFNLPLN
    61  RGLERALEEA ANSGGLNLSA RKLKEFPRTA APGHDLSDTV QADLSKNRLV EVPMELCHFV
   121  SLEILNLYHN CIRVIPEAIV NLQMLTYLNL SRNQLSALPA CLCGLPLKVL IASNNKLGSL
   181  PEEIGQLKQL MELDVSCNEI TALPQQIGQL KSLRELNVRR NYLKVLPQEL VDLSLVKFDF
   241  SCNKVLVIPI CFREMKQLQV LLLENNPLQS PPAQICTKGK VHIFKYLSIQ ACQIKTADSL
   301  YLHTMERPHL HQHVEDGKKD SDSGVGSDNG DKRLSATEPS DEDTVSLNVP MSNIMEEEQI
   361  IKEDSCHRLS PVKGEFHQEF QPEPSLLGDS TNSGEERDQF TDRADGLHSE FMNYKARAED
   421  CEELLRIEED VHWQTEGIIS SSKDQDMDIA MIEQLREAVD LLQDPNGLST DITERSVLNL
   481  YPMGSAEALE LQDSALNGQI QLETSPVCEV QSDLTLQSNG SQYSPNEIRE NSPAVSPTTN
   541  STAPFGLKPR SVFLRPQRNL ESIDPQFTIR RKMEQMREEK ELVEQLRESI EMRLKVSLHE
   601  DLGAALMDGV VLCHLVNHIR PRSVASIHVP SPAVPKLSMA KCRRNVENFL EACRKLGVPE
   661  ADLCSPCDIL QLDFRHIRKT VDTLLALGEK APPPTSALRS RDLIGFCLVH ILFIVLVYIT
   721  YHWNALSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRCH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 36 nTPM
blood vessel: 20 nTPM
skin: 17 nTPM
thymus: 17 nTPM
placenta: 17 nTPM
smooth muscle: 16 nTPM

Single-cell type

distal convoluted tubule cells: 744 nCPM
microglia: 583 nCPM
bergmann glia: 508 nCPM
renal connecting tubule cells: 378 nCPM
vascular endothelial cells: 301 nCPM
cone photoreceptor cells: 280 nCPM

Immune cell

naive B-cell: 2.7 nTPM
NK-cell: 2.5 nTPM
memory B-cell: 2.2 nTPM
gdT-cell: 1.5 nTPM
memory CD4 T-cell: 1.1 nTPM
memory CD8 T-cell: 1 nTPM

Brain region

cerebellum: 81 nTPM
spinal cord: 21 nTPM
pons: 21 nTPM
white matter: 20 nTPM
thalamus: 19 nTPM
medulla oblongata: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.28
gnomAD pLI: 1
gnomAD missense Z: 1.39
DepMap mean gene effect: 0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRCH1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRCH1 as an antibody target. Whether an autoantibody or antibody against LRCH1 could matter depends on whether native LRCH1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRCH1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRCH1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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