Seroatlas · Human Serome Atlas

LRRC63

Leucine-rich repeat-containing protein 63

Also known as: LRC63_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q05C16
Gene: LRRC63
Canonical length: 587 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for LRRC63 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

587 residues, UniProt reviewed canonical sequence.

>Q05C16|LRRC63
     1  MQKPPLLLRR PLPPKFTKLS LHEKKTHTAK TGKIESLHVA FTEDETTSIK MDRTRFPDVL
    61  RNQSLTPINI QNIFLDHCVQ ERVTAISSPQ KSTKHVREQI PDTATGSIFF PHCNSASTRI
   121  FGKQTNKMES SRKFKTMKDV YTEKRLENIL ILSSKFSKPK STPGSVIAQK LEKMHPKHQP
   181  LPESPGYTYQ HISRDLSATV PSPPPMTVSM KPEGQWPEHF KSTATLTLRV TEFPGFVSLP
   241  TPVLPRKPHR QSVIETLVTE NGNIESVPKQ IPPRPPEGLT KTEKIESEIH VVRGEGFKTV
   301  AATRYETITA MTNLAIVNCQ VYGRNALNLK GFFILNCPDL TPLAFQLIYL NLSFNDLHYF
   361  PTEILCLKNL QILKLRNNPI KEIPSEIQQL EFLRIFTIAF NLITVLPIGL FSLSYLEELD
   421  VSYNELTFIP NEIQKLRSLE KLTVDGNELS FFPHGILKLN LTKIQFENNF THPCFWRDNY
   481  LNNPQQLTQI ISLFIVQNKL HKFYDKIPVE VQKLLKCTSR CEWCHGPKFG EGFRVIRSCD
   541  IFGASQLPVM FYVCSPSCYR RIKESSFVLD GSPSRRIALD VELSKEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC63 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 9.9 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 9.9 nTPM
midbrain: 3.5 nTPM
testis: 3.2 nTPM
epididymis: 2.2 nTPM
retina: 2.2 nTPM
hippocampal formation: 1.6 nTPM

Single-cell type

oligodendrocytes: 203 nCPM
early spermatids: 130 nCPM
ependymal cells: 96 nCPM
late primary spermatocytes: 76 nCPM
respiratory ciliated cells: 73 nCPM
fallopian tube ciliated cells: 48 nCPM

Immune cell

plasmacytoid DC: 0.5 nTPM
memory CD8 T-cell: 0.3 nTPM
naive CD4 T-cell: 0.2 nTPM
naive CD8 T-cell: 0.2 nTPM
gdT-cell: 0.1 nTPM
MAIT T-cell: 0.1 nTPM

Brain region

white matter: 20 nTPM
medulla oblongata: 14 nTPM
pons: 10 nTPM
cerebellum: 9.8 nTPM
basal ganglia: 9.6 nTPM
spinal cord: 9.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0
gnomAD missense Z: 0.96
DepMap mean gene effect: 0.12
DepMap dependency class: none

OntologyGO

Biological processes

intracellular signal transduction

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC63 as an antibody target. Whether an autoantibody or antibody against LRRC63 could matter depends on whether native LRRC63 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC63 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC63 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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