Seroatlas · Human Serome Atlas

LRRC39

Leucine-rich repeat-containing protein 39

Also known as: LRC39_HUMAN, MGC14816, myomasp

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96DD0
Gene: LRRC39
Ensembl: ENSG00000122477
Chromosome: 1
Canonical length: 335 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in intracellular signal transduction. Predicted to be located in M band. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

335 residues, UniProt reviewed canonical sequence.

>Q96DD0|LRRC39
     1  MTENVVCTGA VNAVKEVWEK RIKKLNEDLK REKEFQHKLV RIWEERVSLT KLREKVTRED
    61  GRVILKIEKE EWKTLPSSLL KLNQLQEWQL HRTGLLKIPE FIGRFQNLIV LDLSRNTISE
   121  IPPGIGLLTR LQELILSYNK IKTVPKELSN CASLEKLELA VNRDICDLPQ ELSNLLKLTH
   181  LDLSMNDFTT IPLAVLNMPA LEWLDMGSNK LEQLPDTIER MQNLHTLWLQ RNEITCLPQT
   241  ISNMKNLGTL VLSNNKLQDI PVCMEEMANL RFVNFRDNPL KLKVSLPPSE GTDEEEEREL
   301  FGLQFMHTYI QESRRRADHQ VNGSTTLPIS INTDG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC39 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 404 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 404 nTPM
tongue: 161 nTPM
retina: 109 nTPM
heart muscle: 100 nTPM
adrenal gland: 7.9 nTPM
testis: 5.3 nTPM

Single-cell type

myonuclei: 784 nCPM
rod photoreceptor cells: 357 nCPM
cone photoreceptor cells: 302 nCPM
late primary spermatocytes: 282 nCPM
hofbauer cells: 247 nCPM
cardiomyocytes: 150 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 8.7 nTPM
cerebral cortex: 8.2 nTPM
medulla oblongata: 8 nTPM
hypothalamus: 7.8 nTPM
basal ganglia: 7.5 nTPM
amygdala: 7.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.83
gnomAD pLI: 0
gnomAD missense Z: 0.26
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

intracellular signal transduction

Cellular components

M band

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRRC39 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

MYH7

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC39 as an antibody target. Whether an autoantibody or antibody against LRRC39 could matter depends on whether native LRRC39 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC39 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC39 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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