Seroatlas · Human Serome Atlas

LRRC69

Leucine-rich repeat-containing protein 69

Also known as: LRC69_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZNQ3
Gene: LRRC69
Ensembl: ENSG00000214954
Chromosome: 8
Canonical length: 347 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

Predicted to be involved in intracellular signal transduction. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

347 residues, UniProt reviewed canonical sequence.

>Q6ZNQ3|LRRC69
     1  MTERLLIKAL SGGKNTKIIT LNGKKMTKMP SALGKLPGLK TLVLQNNLIP KVCPELCNLT
    61  QLTTLNLGNN LLEEVPEEMK YLTSLKNLHL SGNRICRFAP GACDGLQNLI LLNLNNNHLT
   121  QLPQEVSRLK SLTYMSINYN QLASIPRELC FLENLVELQL NYNQLICIPE EIKFLKKLQK
   181  LLLARNNIGV LPEELCDLKK LRILDIAGNI IQIFPSGFQD LKLREFYCEG NPLFLQQPVI
   241  STQQENVWSL QEITSRFVMN QLAENNPFLM DDIERYPQVR SMISQGKTCA ICGQYFITVW
   301  LECVRFVPPP KDWKISKNLK LVPLQVLICS YKCFTQRDPN LFGIAQV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC69 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 2.7 nTPM

Expression across tissuesHPA

Tissue

testis: 2.7 nTPM
skin: 1.4 nTPM
lymph node: 0.8 nTPM
parathyroid gland: 0.8 nTPM
appendix: 0.7 nTPM
smooth muscle: 0.7 nTPM

Single-cell type

late primary spermatocytes: 101 nCPM
adrenal cortex cells: 69 nCPM
microglia: 63 nCPM
ependymal cells: 57 nCPM
choroid plexus epithelial cells: 52 nCPM
adipocytes: 41 nCPM

Immune cell

T-reg: 0.5 nTPM
naive B-cell: 0.4 nTPM
naive CD4 T-cell: 0.4 nTPM
plasmacytoid DC: 0.4 nTPM
eosinophil: 0.3 nTPM
memory CD4 T-cell: 0.3 nTPM

Brain region

white matter: 2.6 nTPM
choroid plexus: 2.4 nTPM
medulla oblongata: 2.3 nTPM
pons: 2.1 nTPM
basal ganglia: 1.8 nTPM
cerebellum: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0
gnomAD missense Z: 0.6

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

intracellular signal transduction

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC69 as an antibody target. Whether an autoantibody or antibody against LRRC69 could matter depends on whether native LRRC69 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC69 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC69 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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