Seroatlas · Human Serome Atlas

LRCH3

DISP complex protein LRCH3

Also known as: LRCH3_HUMAN, MGC4126

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96II8
Gene: LRCH3
Ensembl: ENSG00000186001
Chromosome: 3
Canonical length: 777 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Involved in septin cytoskeleton organization. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

777 residues, UniProt reviewed canonical sequence.

>Q96II8|LRCH3
     1  MAAAGLVAVA AAAEYSGTVA SGGNLPGVHC GPSSGAGPGF GPGSWSRSLD RALEEAAVTG
    61  VLSLSGRKLR EFPRGAANHD LTDTTRADLS RNRLSEIPIE ACHFVSLENL NLYQNCIRYI
   121  PEAILNLQAL TFLNISRNQL STLPVHLCNL PLKVLIASNN KLVSLPEEIG HLRHLMELDV
   181  SCNEIQTIPS QIGNLEALRD LNVRRNHLVH LPEELAELPL IRLDFSCNKI TTIPVCYRNL
   241  RHLQTITLDN NPLQSPPAQI CIKGKVHIFK YLNIQACKIA PDLPDYDRRP LGFGSCHEEL
   301  YSSRPYGALD SGFNSVDSGD KRWSGNEPTD EFSDLPLRVA EITKEQRLRR ESQYQENRGS
   361  LVVTNGGVEH DLDQIDYIDS CTAEEEEAEV RQPKGPDPDS LSSQFMAYIE QRRISHEGSP
   421  VKPVAIREFQ KTEDMRRYLH QNRVPAEPSS LLSLSASHNQ LSHTDLELHQ RREQLVERTR
   481  REAQLAALQY EEEKIRTKQI QRDAVLDFVK QKASQSPQKQ HPLLDGVDGE CPFPSRRSQH
   541  TDDSALCMSL SGLNQVGCAA TLPHSSAFTP LKSDDRPNAL LSSPATETVH HSPAYSFPAA
   601  IQRNQPQRPE SFLFRAGVRA ETNKGHASPL PPSAAPTTDS TDSITGQNSR QREEELELID
   661  QLRKHIEYRL KVSLPCDLGA ALTDGVVLCH LANHVRPRSV PSIHVPSPAV PKLTMAKCRR
   721  NVENFLEACR KIGVPQEQLC LPLHILEEKG LSQVAVTVQA LLELAPPKQQ QHQLSAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRCH3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 19 nTPM
retina: 18 nTPM
tonsil: 18 nTPM
lymph node: 16 nTPM
thymus: 14 nTPM
blood vessel: 14 nTPM

Single-cell type

myonuclei: 287 nCPM
oligodendrocytes: 266 nCPM
fibro-adipogenic progenitors: 225 nCPM
melanocytes: 222 nCPM
lactotrophs: 218 nCPM
oligodendrocyte progenitor cells: 207 nCPM

Immune cell

basophil: 39 nTPM
eosinophil: 10 nTPM
memory B-cell: 9.3 nTPM
naive CD8 T-cell: 7.5 nTPM
gdT-cell: 7.4 nTPM
NK-cell: 7.1 nTPM

Brain region

cerebellum: 55 nTPM
white matter: 48 nTPM
hypothalamus: 42 nTPM
basal ganglia: 41 nTPM
cerebral cortex: 38 nTPM
medulla oblongata: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.81
gnomAD pLI: 0
gnomAD missense Z: 0.28
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

septin cytoskeleton organization

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRCH3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRCH3 as an antibody target. Whether an autoantibody or antibody against LRCH3 could matter depends on whether native LRCH3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRCH3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRCH3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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